Brain iron load and neuroaxonal vulnerability in adult attention-deficit hyperactivity disorder

Article Article scientifique Article Brain iron load and neuroaxonal vulnerability in adult attention-deficit hyperactivity disorder eng 2025-02-27 author Berberat Jatta Elina 0000-0002-6551-8308 Division of Geriatric Psychiatry, University Hospitals of Geneva (HUG), Thônex, Switzerland.,Department of Psychiatry, University of Geneva (UniGE), Geneva, Switzerland.,Institute of Neuroradiology, Kantonsspital Aarau, Aarau, Switzerland. 978957 author Kagerer Sonja Department of Psychiatry, University of Geneva (UniGE), Geneva, Switzerland.,Department of Geriatric Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich.,Institute for Regenerative Medicine (IREM), University of Zurich, Schlieren, Switzerland. 665338 Département de psychiatrie (PSYAT) author Spani Claudia Department of Psychiatry, University of Geneva (UniGE), Geneva, Switzerland.,Department of Geriatric Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich. 958919 author Hua Jun Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.,F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA. author Bavato Francesco Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, Zurich, Switzerland. author Gruber Philipp Institute of Neuroradiology, Kantonsspital Aarau, Aarau, Switzerland. author van Zijl Peter Cm Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.,F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA. author Perroud Nader Ali 0000-0002-9282-9216 Department of Psychiatry, University of Geneva (UniGE), Geneva, Switzerland. 94458 Département de psychiatrie (PSYAT) author Li Xu Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.,F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA. author Stämpfli Philipp Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, Zurich, Switzerland. author Seifritz Erich Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, Zurich, Switzerland.,Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology, Zurich, Switzerland. author Lövblad Karl-Olof Division of Diagnostic and Interventional Neuroradiology, Geneva University Hospitals and Faculty of Medicine of Geneva, Geneva, Switzerland. 135154 Département de radiologie et informatique médicale (RADIO) author Quednow Boris B Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, Zurich, Switzerland.,Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology, Zurich, Switzerland. author Unschuld Paul 0000-0002-6116-3386 Division of Geriatric Psychiatry, University Hospitals of Geneva (HUG), Thônex, Switzerland.,Department of Psychiatry, University of Geneva (UniGE), Geneva, Switzerland. 951221 Département de psychiatrie (PSYAT) 10.1111/pcn.13806 40013605 1323-1316 https://onlinelibrary.wiley.com/doi/10.1111/pcn.13806 Aim: Adult attention deficit hyperactivity disorder (ADHD) may be associated with an increased risk of dementia in old age. Here, we investigated the liability for neurodegenerative brain disease in adult ADHD, possibly reflected by increased brain iron content and associated neuroaxonal vulnerability. Methods: Thirty-two adults with ADHD (35 ± 10 years) and 29 age- and sex-matched controls (32 ± 12 years) underwent magnetic resonance imaging (MRI), standardized psychometric testing and assessment of lifestyle factors. Quantitative susceptibility mapping (QSM) was used to assess magnetic abnormalities indicating local alterations of iron deposition in the brain. By calculating QSM-maps, local iron deposition was tested for statistically significant differences between ADHD and healthy controls. Plasma neurofilament light chain (NfL) levels were measured as an indicator of neuroaxonal integrity by using a fourth-generation ELLA immunoassay. Results: Brain iron content differed in persons with ADHD, with strongest effects observable in the right precentral cortex (healthy controls: 0.0033 ± 0.0017ppm; ADHD: 0.0048 ± 0.0016ppm; t(59) = 3.56, P < 0.001). Moreover, right precentral cortex iron in persons with ADHD was associated with increased blood NfL levels (F(1.57) = 13.2, P = 0.001, r2 = 0.19). Conclusion: Our results indicate altered regional iron content in the brains of adults with ADHD. The observed association between increased precentral magnetic susceptibility and increased NfL suggests a connection between local excess of brain iron and neuroaxonal damage in ADHD. Given the limited sample size of the current study and the naturalistic medication plan, further longitudinal studies are needed to establish whether altered brain iron distribution in adults with ADHD may be associated with an increased risk of dementia at old age. ADHD MRI NfL Dementia Iron Dewey 616.89 Dewey 616.0757 NIBIB NIH HHS P41 EB031771 United States Stiftung Synapsis - Alzheimer Forschung Schweiz AFS 2018-PI06 Swiss National Science Foundation Cerebral Small Vessel Disease in Adult Attention-Deficit Hyperactivity Disorder. 190510 CH Projects Swiss National Science Foundation Non-heme brain iron burden and neuroaxonal injury in adolescence and middle age 192480 CH Projects 62 Département de radiologie et informatique médicale 227 60 Département de psychiatrie 225 false 470 Ischémie cérébrale et connectivité 801 1342 Régulation des émotions : TDAH et trouble de la personnalité borderline 1028 1389 Santé mentale gériatrique et médecine de précision 1041 Psychiatry and clinical neurosciences 7ea873c7-cf93-4edb-a3ec-65c655abc71f Article (Published version) Public file.pdf 2696018 application/pdf CC BY-4.0 02292aaa0a7abc9c100320cd5297d4eaa5ebab6da9f028e39e36488ddc9f8a33 openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Brain iron load and neuroaxonal vulnerability in adult attention-deficit hyperactivity disorder	Psychiatry and clinical neurosciences			2025	198	110

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