Premorbid aspirin use is not associated with lower mortality in older inpatients with SARS-CoV-2 pneumonia

Article Article scientifique Article Premorbid aspirin use is not associated with lower mortality in older inpatients with SARS-CoV-2 pneumonia eng 2022-01-07 2022-04 author Sullerot Coralie Department of Geriatric Internal Medicine, Dijon University Hospital, Dijon, France. author Bouiller Kevin 0000-0002-2177-4318 Department of Infectious Diseases, Besançon University Hospital, Besançon, France. author Laborde Marie-Caroline Department of Geriatric Internal Medicine, Nimes University Hospital, Nimes, France. 958614 author Gilis Marine Department of Geriatrics, Besançon University Hospital, Besançon, France. author Fèvre Amélie Department of Geriatric Internal Medicine, Nimes University Hospital, Nimes, France. author Hacquin Arthur Department of Geriatric Internal Medicine, Dijon University Hospital, Dijon, France. author Manckoundia Patrick Department of Geriatric Internal Medicine, Dijon University Hospital, Dijon, France. author Hoefler Florence Department of Internal Medicine and Infectious Diseases, Troyes Hospital, Troyes, France. author Bermejo Messaline Department of Internal Medicine and Infectious Diseases, Troyes Hospital, Troyes, France. author Mendes Aguiar Santos Aline Division of Geriatrics, Geneva University Hospitals, Geneva, Switzerland. 847282 author De Roux Serratrice Christine 0000-0001-9940-4686 Division of Internal Medicine for the Aged, Geneva University Hospitals, Geneva, Switzerland. 942516 dept de réadaptation et gériatrie (MIGRG) author Prendki Virginie 0000-0003-1315-2938 Division of Internal Medicine for the Aged, Geneva University Hospitals, Geneva, Switzerland.,Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland. 811987 dept de réadaptation et gériatrie (MIGRG) author Sanchez Stéphane Department of Clinical Research, Troyes Hospital, Troyes, France. author Putot Alain 0000-0002-4408-554X Department of Geriatric Internal Medicine, Dijon University Hospital, Dijon, France. alain.putot@chu-dijon.fr.,Service de Médecine Interne Gériatrie, Hôpital de Champmaillot CHU, 21079, Dijon Cedex, France. alain.putot@chu-dijon.fr. ESGIE 573-583 10.1007/s11357-021-00499-8 34993763 2509-2723 PMC8736303 https://link.springer.com/article/10.1007/s11357-021-00499-8 Platelet aggregation has been associated with COVID-19 pathogenesis. In older patients hospitalized for SARS-CoV-2 pneumonia, we aimed to investigate the association between aspirin use before admission and the risk of in-hospital all-cause mortality. We performed a retrospective international cohort study in five COVID-19 geriatric units in France and Switzerland. Among 1,357 consecutive hospitalized patients aged 75 or older and testing positive for SARS-CoV-2, we included 1,072 with radiologically confirmed pneumonia. To adjust for confounders, a propensity score for treatment was created, and stabilized inverse probability of treatment weighting (SIPTW) was applied. To assess the association between aspirin use and in-hospital 30-day mortality, SIPTW-adjusted Kaplan-Meier and Cox proportional hazards regression analyses were performed. Of the 1047 patients with SARS-CoV-2 pneumonia and median age 86 years, 301 (28.7%) were taking aspirin treatment before admission. One hundred forty-seven (34.3%) patients who had taken aspirin died in hospital within 1 month vs 118 patients (30.7%) without aspirin. After SIPTW, aspirin treatment was not significantly associated with lower mortality (adjusted hazard ratio: 1.10 [0.81-1.49], P = .52). Moreover, patients on aspirin had a longer hospital stay and were more frequently transferred to the intensive care unit. In a large multicenter cohort of older inpatients with SARS-CoV-2 pneumonia, aspirin use before admission did not appear to be associated with an improved prognosis. Aged Antiplatelet Aspirin COVID-19 Coronavirus Mortality Pneumonia Aged, 80 and over Aspirin / therapeutic use Cohort Studies Humans Inpatients Retrospective Studies SARS-CoV-2 Dewey 616 Dewey 618.97 56 Département de médecine 221 65 Département de réadaptation et gériatrie 22B false GeroScience 44 2 e6e111f6-03e8-46d6-96a4-d2f1bdc766ee Article (Published version) Public Article-scientifique-from-europePmc.pdf 681152 application/pdf 510725487949f1eea94d99e0e0da905809fe8bf6480168b6c4bafdef8715e5ac openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

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Premorbid aspirin use is not associated with lower mortality in older inpatients with SARS-CoV-2 pneumonia	GeroScience			2022	67	64

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Laborde, Marie-Caroline