Transcriptional regulation in the obligate intracellular human pathogen Orientia tsutsugamushi

Diplôme Thèse Transcriptional regulation in the obligate intracellular human pathogen Orientia tsutsugamushi eng 2025-06-23 2025-06-23 director Viollier Patrick 0000-0002-5249-9910 706923 Département de microbiologie et médecine moléculaire (MIMOL) author Kriach Amane 956144 director Panis Gaël 743525 Section des sciences pharmaceutiques (FARMA) 219 10.13097/archive-ouverte/unige:187397 urn:nbn:ch:unige-1873977 Sc. Vie - Bioméd. 347 Alpha-proteobacteria represent a diverse group of Gram-negative bacteria that inhabit a wide range of ecological niches, including associations with animals and plants, and exhibit lifestyles ranging from intracellular parasitism and endosymbiosis to free-living proliferation. This group has been extensively studied in the context of bacterial cell cycle regulation, particularly through the free-living model Caulobacter crescentus, which has provided foundational insights into the coordination of bacterial growth and division. In contrast, Orientia tsutsugamushi, a member of the Rickettsiales order, is an obligatory intracellular bacterium and the causative agent of scrub typhus, a neglected tropical disease of increasing public health concern. Despite its clinical relevance and highly specialized lifestyle, the regulatory mechanisms that govern gene expression in O. tsutsugamushi remain largely uncharacterized. This thesis aims to shed light on how transcriptional regulators participate to orchestrate gene expression across the two distinct stages of O. tsutsugamushi’s life cycle, intracellular and extracellular, with a particular focus on two signature proteins, TrcR and CtrA, originally identified in C. crescentus and highly conserved among Alpha-proteobacteria but whose regulon remains largely unknown Rickettsiales. Alpha-proteobacteria Rickettsiales Orientia tsutsugamushi Scrub typhus Transcriptional regulation CtrA TrcR Dewey 616 Swiss National Science Foundation Developmental transcription in the obligate intracellular bacterium causing scrub typhus 193925 CH Programmes 54 Département de microbiologie et médecine moléculaire 21B false 554 Régulation du cycle cellulaire dans C.crescentus, une bactérie asymétrique 895 cd655b05-954c-4e83-8ccc-22927fa0da59 Thesis Restricted Amane_KRIACH_thesis.pdf 9556846 application/pdf 1236ace8c824975325a36196f8d12ba56c83deacaa4a909d52e27f6b97ff1256 6bf2aa93-9233-4caa-ab13-55214881b175 Imprimatur Public IMPRIMATUR_Amane_KRIACH_signé_par_t.pdf 185963 application/pdf e548e6468aa726994672eaac146fc420f8a5d3abe60428fe80767b54a6e44514 restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire

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Transcriptional regulation in the obligate intracellular human pathogen Orientia tsutsugamushi				2025	195	3

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Kriach, Amane

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