Modulation of STAT6 signaling for hepatoprotection

Article Article scientifique Revue de la littérature Modulation of STAT6 signaling for hepatoprotection eng 2025-12-02 2025 author Somm Emmanuel Service of Endocrinology, Diabetes and Metabolism, Department of Medicine, Geneva University Hospitals/University of Geneva, Geneva, Switzerland.,Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland. 95704 Département de médecine (DEMED) author Rahman Mahdi Service of Endocrinology, Diabetes and Metabolism, Department of Medicine, Geneva University Hospitals/University of Geneva, Geneva, Switzerland.,Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland. 951369 Structure enseignement (ENSI) author Szanto Ildiko 0000-0003-3566-7991 Service of Endocrinology, Diabetes and Metabolism, Department of Medicine, Geneva University Hospitals/University of Geneva, Geneva, Switzerland.,Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 133688 Département de médecine (DEMED) author Gariani Karim Service of Endocrinology, Diabetes and Metabolism, Department of Medicine, Geneva University Hospitals/University of Geneva, Geneva, Switzerland.,Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 542849 Département de médecine (DEMED) author Jornayvaz François 0000-0001-9425-3137 641037 Département de médecine (DEMED) 1659227 10.3389/fphar.2025.1659227 41409600 1663-9812 PMC12705365 https://www.frontiersin.org/articles/10.3389/fphar.2025.1659227/full Signal transducer and activator of transcription (STAT) proteins are a family of seven transcription factors mediating various biological processes. STAT6 is classically known to regulate immune cell biology by transmitting signals from interleukin (IL)-4 and IL-13 into transcriptional activation of genes driving type 2 immunity. In orchestrating T helper lymphocytes and macrophages polarization, STAT6 plays a central role in the regulation of both cellular and humoral immunities. Several pathologies, including inflammatory disorders, autoimmune/allergic diseases, metabolic syndrome as well as cancer, are associated with a dysregulation of type 2 immunity related to inadequate expression and/or activity of STAT6. In the present review, following a brief introduction of STAT6 biology, we summarize the immunologic and physiological roles of STAT6 in the context of liver integrity as well as the potential roles of STAT6-mediated pathways in both hepatoprotection and liver pathophysiological mechanisms. HCC Ischemia-reperfusion MASH MASLD STAT6 Acute liver damage Fibrosis Immune polarization Dewey 616 Swiss National Science Foundation IL-18 signaling in NAFLD/NASH: from mice to humans 215330 CH 56 Département de médecine 221 false 1263 MASLD/MASH et résistance à l'insuline 997 Frontiers in pharmacology 16 6565b0a6-ea33-40b7-ab78-c90cb5f4d1f0 Article (Published version) Public fphar-16-1659227.pdf 2029615 application/pdf CC BY-4.0 56ec1ff09de2a5a7b3c7f17f0fc33bca41723037a566628df2ebc425fe86334b openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Modulation of STAT6 signaling for hepatoprotection	Frontiers in pharmacology			2025	16	132

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