Combined hyperthermia and radiotherapy for prostate cancer: a systematic review

Article Article scientifique Revue de la littérature Combined hyperthermia and radiotherapy for prostate cancer: a systematic review eng 2022 author Le Guevelou Jennifer 0000-0002-9589-4873 981757 author Chirila Monica Emilia 0000-0001-9299-7562 949278 author Achard Verane 0000-0002-5374-8851 885700 author Guillemin Pauline Coralie 0000-0003-2792-6543 877140 author Lorton Orane 0000-0002-6500-1093 855324 author Uiterwijk Johannes 966821 author Dipasquale Giovanna 0000-0002-9225-9559 863384 author Salomir Rares Vincent 0000-0002-4182-0959 682178 author Zilli Thomas 791833 547-556 10.1080/02656736.2022.2053212 35313781 0265-6736 https://www.tandfonline.com/doi/full/10.1080/02656736.2022.2053212 Optimization of treatment strategies for prostate cancer patients treated with curative radiation therapy (RT) represents one of the major challenges for the radiation oncologist. Dose escalation or combination of RT with systemic therapies is used to improve tumor control in patients with unfavorable prostate cancer, at the risk of increasing rates and severity of treatment-related toxicities. Elevation of temperature to a supra-physiological level has been shown to both increase tumor oxygenation and reduce DNA repair capabilities. Thus, hyperthermia (HT) combined with RT represents a compelling treatment strategy to improve the therapeutic ratio in prostate cancer patients. The aim of the present systematic review is to report on preclinical and clinical evidence supporting the combination of HT and RT for prostate cancer, discussing future applications and developments of this combined treatment. Prostate cancer Hyperthermia Radiotherapy Recurrence Toxicity Combined Modality Therapy Humans Hyperthermia Hyperthermia, Induced Male Prostatic Neoplasms / radiotherapy Dewey 616.0757 Swiss National Science Foundation A feasibility study on salvage radiotherapy with adjuvant hyperthermia delivered by MR-guided Transperineal Ultrasound (MRgTUS) for recurrent prostate cancer after radical prostatectomy 320030_182366 CH Project funding Fondation privée des HUG RC06-01 Fondation pour l’Innovation sur le Cancer et la Biologie 62 Département de radiologie et informatique médicale 227 false 926 Imagerie per-opératoire multi-modalité en radiologie interventionnelle 949 International journal of hyperthermia 39 1 5c469adf-42b8-4287-9259-f6584e8113c2 Article (Published version) Public Combined hyperthermia and radiother1.pdf 1856983 application/pdf CC BY-4.0 openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Combined hyperthermia and radiotherapy for prostate cancer: a systematic review	International journal of hyperthermia			2022	191	676

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Chirila, Monica Emilia