Linking cell-surface GRP78 to cancer: From basic research to clinical value of GRP78 antibodies

Article Article scientifique Article Linking cell-surface GRP78 to cancer: From basic research to clinical value of GRP78 antibodies eng 2021-10-09 2022-01 author Hernandez Isabelle 0000-0002-7713-3253 941652 author Cohen Marie-Benoîte 0000-0003-4621-5464 135615 1-14 10.1016/j.canlet.2021.10.004 34637844 0304-3835 https://linkinghub.elsevier.com/retrieve/pii/S0304383521005140 Glucose-related protein 78 (GRP78) is a chaperone protein localized primarily in the endoplasmic reticulum (ER) lumen, where it helps in proper protein folding by targeting misfolded proteins and facilitating protein assembly. In stressed cells, GRP78 is translocated to the cell surface (csGRP78) where it binds to various ligands and triggers different intracellular pathways. Thus, csGRP78 expression is associated with cancer, involved in the maintenance and progression of the disease. Extracellular exposition of csGRP78 leads to the production of autoantibodies as observed in patients with prostate or ovarian cancer, in which the ability to target csGRP78 affects the tumor development. Present on the surface of cancer cells and not normal cells in vivo, csGRP78 represents an interesting target for therapeutic antibody strategies. Here we give an overview of the csGRP78 function in the cell and its role in oncogenesis, thereby providing insight into the clinical value of GRP78 monoclonal antibodies for cancer prognosis and treatment. Cell-surface GRP78 GRP78 antibodies Prognosis Therapy Tumor development Dewey 618 Institut Clayton pour la Recherche 58 Département de pédiatrie, gynécologie et obstétrique 223 false 584 Laboratoire de biologie des tumeurs gynécologiques et du développement 927 Cancer letters 524 e85420c4-6a1d-45a3-b67b-f6616875f0a0 Article (Published version) Public 1-s2.0-S0304383521005140-main.pdf 3417866 application/pdf CC BY-NC-ND-4.0 openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Linking cell-surface GRP78 to cancer: From basic research to clinical value of GRP78 antibodies	Cancer letters			2022	282	284

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Hernandez, Isabelle