Purpura fulminans in a child as a complication of chickenpox infection

Article Article scientifique Rapport de cas Purpura fulminans in a child as a complication of chickenpox infection eng 2004 author Campanelli Alexandre 94476 author Kaya Guerkan 26603 author Ozsahin Ayse Hulya 121635 author La Scala Giorgio 0000-0003-1572-598X 37746 author Jacquier Cédric 94149 author Stauffer Mélanie 87707 author Boehlen Françoise 33004 author De Moerloose Philippe 26335 author Saurat Jean-Hilaire 21995 262-264 10.1159/000077315 15118384 1018-8665 Purpura fulminans is a thrombotic disease that can occur during infections, disseminated intravascular coagulation or in the context of an acquired or congenital protein C or S deficiency. Here we report the case of a 4-year-old child who developed, 5 days after a chickenpox infection, large painful ecchymotic, necrotizing and retiform plaques on the lower extremities. Laboratory analyses revealed very low protein S levels as well as anticardiolipin antibodies. Aggressive treatment by low-molecular-weight heparin, steroids, intravenous immunoglobulins and fresh frozen plasma was able to prevent the extension of the lesions and to correct the coagulation abnormalities. No lesions required skin grafting. As in our patient, an acquired protein S deficiency is probably responsible for most cases of purpura fulminans occurring after varicella, but the concomitant presence of antiphospholipid antibodies may also play a role. Antibodies, Anticardiolipin/blood Chickenpox/complications Child, Preschool Humans Lower Extremity Male Necrosis Protein S Deficiency/complications Purpura, Schoenlein-Henoch/pathology/virology Dewey 613 Dewey 616 Dewey 616.8 Dewey 618 53 Département de neurosciences fondamentales 21A 56 Département de médecine 221 58 Département de pédiatrie, gynécologie et obstétrique 223 64 Département de santé et médecine communautaires 22A false Dermatology 208 3 8e02dee3-f6f0-46b9-b1b3-9c3ffb039a8d Article (Published version) Restricted 262-264.pdf 72056 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Purpura fulminans in a child as a complication of chickenpox infection	Dermatology			2004	504	0

Archive ouverte UNIGE

Jacquier, Cédric