Allogeneic hematopoietic stem cell transplantation in non-Hodgkin lymphoma in Switzerland, 30 years of experience : Sooner is better

Article Article scientifique Article Allogeneic hematopoietic stem cell transplantation in non-Hodgkin lymphoma in Switzerland, 30 years of experience : Sooner is better eng 2022-11-13 2023-02 author Rebmann Ekaterina 0000-0001-9478-4069 Department of Hematology University Hospital of Bern (Inselspital) Bern Switzerland.,Department of Oncology-Hematology Hospital of Neuchâtel (RHNE) Neuchâtel Switzerland. author Nabergoj Mitja Department of Hematology L'Hôpital Riviera-Chablais Vaud-Valais Switzerland. author Grandjean Bastien Department of Hematology University Hospital of Bern (Inselspital) Bern Switzerland. author Stakia Paraskevi Department of Hematology Geneva University Hospitals (HUG) Genève Switzerland. 941400 author Stern Alix Department of Oncology-Hematology Hospital of Neuchâtel (RHNE) Neuchâtel Switzerland.,Faculty of Medicine University of Basel Basel Switzerland. author Medinger Michael 0000-0003-0427-7747 Department of Hematology University Hospital of Basel (USB) Basel Switzerland. author Masouridi Levrat Stavroula Department of Hematology Geneva University Hospitals (HUG) Genève Switzerland. 844685 Département de médecine (DEMED) author Dantin Carole Alice Department of Hematology Geneva University Hospitals (HUG) Genève Switzerland. 90319 author Schanz Urs Department of Hematology University Hospital of Zurich (UZH) Zürich Switzerland. author Baldomero Helen Department of Hematology University Hospital of Basel (USB) Basel Switzerland.,SBST Data Registry Office Univesiry Hospital of Basel Basel Switzerland. author Passweg Jakob Department of Hematology University Hospital of Basel (USB) Basel Switzerland.,Faculty of Medicine University of Basel Basel Switzerland. 632725 author Nair Gayathri Department of Hematology University Hospital of Zurich (UZH) Zürich Switzerland. author Rovo Alicia 0000-0002-7757-4753 Department of Hematology University Hospital of Bern (Inselspital) Bern Switzerland. author Chalandon Yves Department of Hematology Geneva University Hospitals (HUG) Genève Switzerland.,Faculty of Medicine University of Geneva Geneva Switzerland. 644957 Département de médecine (DEMED) 258-261 10.1002/jha2.614 36819159 2688-6146 PMC9928653 https://onlinelibrary.wiley.com/doi/10.1002/jha2.614 Due to relatively high nonrelapse mortality (NRM), allogeneic hematopoietic stem cell transplantation (allo-HSCT) in non-Hodgkin's lymphoma (NHL) remains the ultimate line of treatment but the only curable approach in a setting of relapse/refractory disease. Here, we conducted a retrospective, multicenter, registry-based analysis on patients who underwent allo-HSCT for NHL in Switzerland, over 30-year (1985-2020) period. The study included 301 allo-HSCTs performed for NHL patients in three University Hospitals of Switzerland (Zurich, Basel and Geneva) 09/1985 to 05/2020. We assessed in univariate and multivariable analysis the impact on survivals (overall survival [OS], relapse free survival [RFS], relapse incidence [RI], and non-treatment related mortality [NRM]). The maximum follow-up was 25 years with median follow-up for alive patients of 61 months. The median age at allo-HSCT was 51 years. Three- and -year OS was - 59.5% and 55.4%; 3- and 5-year PFS was 50% and 44%; 3- and 5-year NRM was 21.7% and 23.6%. RI at 3 and 5 years was 27.4% and 34.9%. In conclusion, our analysis of the entire Swiss experience of allo-HSCT in patients with NHL shows promising 5- and possibly 10-year OS and relatively acceptable NRM rates for such population, the majority being not in complete remission (CR) at the time of transplantation. GVHD Lymphomas Stem cell transplantation Dewey 616 56 Département de médecine 221 false 1216 Leucémie et transplantation allogénique de cellules souches hématopoïétiques 982 EJHaem 4 1 0962e64f-c0ef-4dde-b772-c5861be76828 Article (Published version) Public JHA2-4-258.pdf 209109 application/pdf CC BY-4.0 23d7f4228a591bb8ce2180c6bebff61fb663766a010cd1462b21585cc599c21b openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Allogeneic hematopoietic stem cell transplantation in non-Hodgkin lymphoma in Switzerland, 30 years of experience : Sooner is better	EJHaem	2023	70	119
Saignements d’origine indéterminée : approche diagnostique et thérapeutique	Revue médicale suisse	2022	89	340

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