Economic burden of chronic obstructive pulmonary disease and post-tuberculosis sequelae in low- and middle-income countries : a database compiled from a systematic review and meta-analysis

Article Article scientifique Article Economic burden of chronic obstructive pulmonary disease and post-tuberculosis sequelae in low- and middle-income countries : a database compiled from a systematic review and meta-analysis eng 2024-07-30 2024-06 author Lin Yuling 0000-0002-3834-4111 Institute of Global Health, University of Geneva, Geneva, Switzerland. 937086 author Walker Alexandra Swiss Tropical and Public Health Institute, Allschwil, Switzerland.,University of Basel, Basel, Switzerland. author Batta Marguerite Swiss Tropical and Public Health Institute, Allschwil, Switzerland.,University of Basel, Basel, Switzerland. author Ottilie-Kovelman Sierra Swiss Tropical and Public Health Institute, Allschwil, Switzerland.,Health Policy and Management, Yale University School of Public Health, New Haven, Connecticut, USA. author Duchenko Anna Swiss Tropical and Public Health Institute, Allschwil, Switzerland.,University of Basel, Basel, Switzerland. author Brugger Curdin 0000-0001-8586-4171 Swiss Tropical and Public Health Institute, Allschwil, Switzerland.,University of Basel, Basel, Switzerland. author Keiser Olivia 0000-0001-8191-2789 Institute of Global Health, University of Geneva, Geneva, Switzerland. 873427 Institut de santé globale (COSPR) author Wallis Robert S The Aurum Institute, Parktown, South Africa. author Reither Klaus Swiss Tropical and Public Health Institute, Allschwil, Switzerland.,University of Basel, Basel, Switzerland. author Tediosi Fabrizio 0000-0001-8671-9400 Swiss Tropical and Public Health Institute, Allschwil, Switzerland.,University of Basel, Basel, Switzerland. author Antillon Marina 0000-0002-0235-6030 Swiss Tropical and Public Health Institute, Allschwil, Switzerland.,University of Basel, Basel, Switzerland. e000441 10.1136/bmjph-2023-000441 40018115 2753-4294 PMC11816951 https://bmjpublichealth.bmj.com/content/2/1/e000441 Background: Chronic obstructive pulmonary disease (COPD) and tuberculosis (TB) impose a substantial economic burden globally. This systematic review summarised the evidence on the costs of COPD, including post-TB diseases in low- and middle-income countries. Methods: A systematic review was conducted and studies published between 1 January 2013 and 28 March 2022 (the date of the search) were identified using various electronic databases without language restrictions. Titles, abstracts and full texts were screened in duplicate and data were extracted and verified by reviewers. Eligible studies were categorised as cost analysis and/or economic burden studies, and costs were converted to 2021 United State dollar. Meta-analysis was conducted on the costs of hospitalisations, medication and outpatient visits. Results: 128 cost studies and 65 economic burden studies were included in this review. The data collected are presented in the Cost Database of COPD and Post-TB (CD-CPTB). The majority of studies were from Asia, Eastern Europe and Latin America, with a few from other middle-income countries. There were extremely limited data on the costs of post-TB sequelae and only a few studies were from Africa (n=6) and low-income (n=5) countries. The direct medical costs of COPD ranged from $26 per hospitalisation in India to $2694 per year per patient with severe disease in Mexico, while the costs of acute exacerbation of COPD ranged from $137 to $4207 per exacerbation with both the minimum and maximum costs occurring in Turkey. The costs were lower in lower middle-income countries compared with upper middle-income countries. Finally, considerable economic burden was attributable to smoking and air pollution. Conclusion: The review and the CD-CPTB database give a thorough snapshot of the current evidence of the costs and economic burden of COPD and post-TB diseases. Future research is needed to investigate the economic impact after TB treatment and should be prioritised in Africa and low-income countries where there has been a lack of data collection. Protocol registration number: CRD42022326609. Comorbidity Endemic Diseases Public Health Economics Dewey 613 European Commission STRATIFIED HOST-DIRECTED THERAPY FOR DRUG-RESISTANT TUBERCULOSIS: A RANDOMIZED CONTROLLED MULTI-CENTRE TRIAL 847465 DRTB-HDT EU H2020 66 Institut de santé globale 22A1 false 1246 Maladies infectieuses et modèles mathématiques 988 BMJ public health 2 1 65ffee8d-b05d-49a7-bad3-1b4f7020e3b4 Article (Published version) Public LinY_2024.pdf 3097633 application/pdf CC BY-4.0 3be15626ab9e83c9ce09692fe6a0ed2a60161860ee6c511adcc6bcabd9b1eb22 f4533701-6eb9-4ca5-b0a6-6d5356cfa945 Appendix Public bmjph-2-1-s001.pdf 436381 application/pdf 2af0f9d50d52e788e233fe7ac6038792a17986b75fad5bf20fc69a87fe420e26 37c10329-6e29-489c-a092-a0416c59a080 Appendix Public bmjph-2-1-s002.pdf 969282 application/pdf 209d270e98dca6292c9bd9255a288494447e82fdcd85be9bdbe276800f1cb1e5 111f5960-b2b8-4980-b5bf-5bbc90403816 Appendix Public bmjph-2-1-s003.pdf 744087 application/pdf 42a827f5bb3b6d0d5cf375ccd14efce9011801255c27a2aa36d891025004b83a 2a5fe662-22ac-4140-ab56-38bfcdd99d4a Appendix Public bmjph-2-1-s004.pdf 7392968 application/pdf bacba0a93b39e1bf7d0b483f7910cb2bd6b2fe0d3a82dbb22f3451eb4eff2a25 openAccess Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut de santé globale

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Economic burden of chronic obstructive pulmonary disease and post-tuberculosis sequelae in low- and middle-income countries : a database compiled from a systematic review and meta-analysis	BMJ public health			2024	11	98

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Lin, Yuling