Cortico-muscular connectivity is modulated by passive and active Lokomat-assisted Gait

Article Article scientifique Article Cortico-muscular connectivity is modulated by passive and active Lokomat-assisted Gait eng 2023-12-07 2023-12-07 author Artoni Fiorenzo 0000-0002-0967-6643 935275 Département des neurosciences cliniques (OTONO) author Cometa Andrea author Dalise Stefania author Azzollini Valentina 0000-0002-1728-9192 author Micera Silvestro author Chisari Carmelo 21618 10.1038/s41598-023-48072-x 38062035 2045-2322 PMC10703891 https://www.nature.com/articles/s41598-023-48072-x The effects of robotic-assisted gait (RAG) training, besides conventional therapy, on neuroplasticity mechanisms and cortical integration in locomotion are still uncertain. To advance our knowledge on the matter, we determined the involvement of motor cortical areas in the control of muscle activity in healthy subjects, during RAG with Lokomat, both with maximal guidance force (100 GF—passive RAG) and without guidance force (0 GF—active RAG) as customary in rehabilitation treatments. We applied a novel cortico-muscular connectivity estimation procedure, based on Partial Directed Coherence, to jointly study source localized EEG and EMG activity during rest (standing) and active/passive RAG. We found greater cortico-cortical connectivity, with higher path length and tendency toward segregation during rest than in both RAG conditions, for all frequency bands except for delta. We also found higher cortico-muscular connectivity in distal muscles during swing (0 GF), and stance (100 GF), highlighting the importance of direct supraspinal control to maintain balance, even when gait is supported by a robotic exoskeleton. Source-localized connectivity shows that this control is driven mainly by the parietal and frontal lobes. The involvement of many cortical areas also in passive RAG (100 GF) justifies the use of the 100 GF RAG training for neurorehabilitation, with the aim of enhancing cortical-muscle connections and driving neural plasticity in neurological patients. Exercise Therapy / methods Exoskeleton Device Gait / physiology Humans Muscle, Skeletal Walking / physiology Dewey 616.8 Regione Toscana FAS Salute 2018 Ministry of University and Research and European Union A multiscale integrated approach to the study of the nervous system in health and disease - MNESYS Ministero dell'Istruzione, dell'UniversitÃ e della Ricerca PRIN-2017 'INSPECT' 61 Département des neurosciences cliniques 226 false Scientific reports 13 1 4eda5df7-f681-4392-a1ba-d72bd8fbbebd Article (Published version) Public Article-scientifique-from-crossref.pdf 4516147 application/pdf CC BY-4.0 33e4353c43d14436e0731c98c7f7cdbfb40a0684de71fbb4a63dfbe0397052f3 ebfba4fe-d40c-4e3f-8990-5c0c4be95729 Appendix Public 41598_2023_48072_MOESM1_ESM(1).docx 2836184 application/vnd.openxmlformats-officedocument.wordprocessingml.document Suppl. Fig 1-2 a9910cc509ef7e54f3b9930e9c3fa135b8ab6191b3f430606b64fc0b87964431 openAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

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Cortico-muscular connectivity is modulated by passive and active Lokomat-assisted Gait	Scientific reports			2023	87	45

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