Role of Par-4 in GRP78 Translocation

Livre Chapitre de livre Role of Par-4 in GRP78 Translocation eng 2022-01-01 2022 author Bastida Ruiz Daniel 759554 author Childress Alexia 934886 author Cohen Marie-Benoîte 0000-0003-4621-5464 135615 209-238 10.1007/978-3-030-73572-2_7 978-3-030-73571-5 https://link.springer.com/10.1007/978-3-030-73572-2_7 GRP78 is a classical endoplasmic reticulum (ER)-localized protein, acting as a chaperone and master regulator of the unfolding protein response in this location. Interestingly, under certain conditions, GRP78 is also located at the cell surface. More concretely, it was observed at the cell surface of several types of cancer cells, but also of trophoblastic cells and stressed cells in general. Cell surface GRP78 can bind to extracellular proteins and promote the activation of different signaling pathways. One of these proteins is prostate apoptosis response 4 (Par-4), a pro-apoptotic protein which is secreted by cancer cells. It was observed that the secretion of Par-4 was increased in parallel with GRP78 cell-surface localization, suggesting a relationship between these events. In this review, we discuss the role of Par-4 in GRP78 relocation at the cell surface. GRP78 Par-4 Endoplasmic reticulum Cell surface Relocation Cancer cell Unfolded protein response Apoptosis Cell survival Cell proliferation Cell fusion Receptor Dewey 618 Cham Springer 58 Département de pédiatrie, gynécologie et obstétrique 223 false 584 Laboratoire de biologie des tumeurs gynécologiques et du développement 927 Tumor Suppressor Par-4: Structural Features, Molecular Mechanisms and Function Rangnekar V. M. d1d2a83f-1ace-4bac-9716-317fc7061759 Book chapter (Accepted version) Restricted Chapter 7 Dr Cohen.pdf 1033600 application/pdf CC BY-ND restrictedAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Role of Par-4 in GRP78 Translocation	Tumor Suppressor Par-4: Structural Features, Molecular Mechanisms and Function			2022	385	3

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Childress, Alexia