Basic characteristics and safety of donation in related and unrelated haematopoietic progenitor cell donors - first 10 years of prospective donor follow-up of Swiss donors

Article Article scientifique Article Basic characteristics and safety of donation in related and unrelated haematopoietic progenitor cell donors - first 10 years of prospective donor follow-up of Swiss donors eng 2022-04-04 2022-06 author Rüesch M 0000-0002-0839-0272 Swiss Blood Stem Cells, Swiss Transfusion SRC (Swiss Red Cross), Berne, Switzerland. morven.ruesch@gmail.com. author Amar El Dusouqui Soraya Regional Blood Transfusion Service SRC, University Hospital, Geneva, Switzerland. author Buhrfeind E Swiss Blood Stem Cells, Swiss Transfusion SRC (Swiss Red Cross), Berne, Switzerland. author Buser A 0000-0002-7942-6746 Regional Blood Transfusion Service SRC, Basel, Switzerland. author Chalandon Yves 0000-0001-9341-8104 Haematology Division, University Hospital, Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 644957 Département de médecine (DEMED) author Frey B M Regional Blood Transfusion Service SRC, Zürich, Switzerland. author Güngör T 0000-0002-3261-1186 University Children's Hospital, Zürich - Eleonore Foundation & Children's Research Center (CRC), Zürich, Switzerland. author Holbro A Regional Blood Transfusion Service SRC, Basel, Switzerland. author Huguet Saadia Haematology Division, University Hospital, Geneva, Switzerland. 934505 author Infanti L Regional Blood Transfusion Service SRC, Basel, Switzerland. author Nair G Medical Oncology and Haematology, University Hospital, Zürich, Switzerland. author Nicoloso G 0000-0001-6783-0349 Swiss Blood Stem Cells, Swiss Transfusion SRC (Swiss Red Cross), Berne, Switzerland. author Passweg J R Haematology, University Hospital, Basel, Switzerland. author Schanz U Medical Oncology and Haematology, University Hospital, Zürich, Switzerland. author Tiercy J-M Swiss Blood Stem Cells, Swiss Transfusion SRC (Swiss Red Cross), Berne, Switzerland. author Widmer I Swiss Blood Stem Cells, Swiss Transfusion SRC (Swiss Red Cross), Berne, Switzerland. author Zeilhofer U Haemato-Oncology, University Hospital for Children, Zürich, Switzerland. author Zurkinden L Swiss Blood Stem Cells, Swiss Transfusion SRC (Swiss Red Cross), Berne, Switzerland. author Halter J P 0000-0003-4304-1956 Haematology, University Hospital, Basel, Switzerland. 918-924 10.1038/s41409-022-01656-z 35379914 0268-3369 https://www.nature.com/articles/s41409-022-01656-z Since July 2007 prospective life-long follow-up (FU) for unrelated (URD) and related donors (RD) is mandatory in Switzerland and data on every allogeneic haematopoietic progenitor cell (HPC) donation are collected prospectively. We report the real-world experience of HPC donation during a 10-year study period (01.07.2007-30.06.2017) with basic characteristics and FU data. 1105 donors underwent 1155 HPC donation procedures. Eighty percent of first donations performed by 802 (73%) RDs and 303 (27%) URDs were peripheral blood stem cells (PBSC), 20% bone marrow (BM). Male donors were over-represented as URD (60% male vs 40% female). Main differences between RDs and URDs concerned age and pre-existing health disorders. RDs were significantly older at first donation (median age 48 years) compared to URD (34 years, p < 0.0001) and had more pre-existing health problems: 25% vs 9% in URD (p < 0.0001). No fatal complications occurred, collection related severe adverse events (SAE) after first donation were not significantly different between groups (RD 1.2%, URD 0.99%), incidence rates for neoplastic and autoimmune diseases did not exceed the rates of the general population. RDs are a more heterogeneous and potentially more vulnerable group, but if donor evaluation is performed appropriately, HPC donation is still safe. Female Follow-Up Studies Hematopoietic Stem Cells Humans Male Middle Aged Prospective Studies Switzerland / epidemiology Tissue Donors Unrelated Donors Dewey 616 56 Département de médecine 221 false 1216 Leucémie et transplantation allogénique de cellules souches hématopoïétiques 982 Bone marrow transplantation 57 6 81a4751a-663b-47a9-8ae1-70292a7b53ca Article (Published version) Restricted basic.pdf 620704 application/pdf 01e6eaa53d2c6d0befd222416fc49b634855c7adfbad3490a8586a7943a63974 restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Basic characteristics and safety of donation in related and unrelated haematopoietic progenitor cell donors - first 10 years of prospective donor follow-up of Swiss donors	Bone marrow transplantation			2022	56	0

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