A common computational principle for vibrotactile pitch perception in mouse and human

Article Article scientifique Article A common computational principle for vibrotactile pitch perception in mouse and human eng 2021-09-09 2021-09-09 author Prsa Mario 0000-0001-5012-2506 795719 author Kilicel Deniz 675521 author Nourizonoz Ali 846708 Département de neurosciences fondamentales (NEUFO) Ali Nouri Zonoz author Lee Kuo-Sheng 0000-0002-2256-4283 934452 Département de neurosciences fondamentales (NEUFO) author Huber Daniel 0000-0002-0744-7679 766211 Département de neurosciences fondamentales (NEUFO) 5336 10.1038/s41467-021-25476-9 34504074 2041-1723 PMC8429766 https://www.nature.com/articles/s41467-021-25476-9 <p>We live surrounded by vibrations generated by moving objects. These oscillatory stimuli propagate through solid substrates, are sensed by mechanoreceptors in our body and give rise to perceptual attributes such as vibrotactile pitch (i.e. the perception of how high or low a vibration’s frequency is). Here, we establish a mechanistic relationship between vibrotactile pitch perception and the physical properties of vibrations using behavioral tasks, in which vibratory stimuli were delivered to the human fingertip or the mouse forelimb. The resulting perceptual reports were analyzed with a model demonstrating that physically different combinations of vibration frequencies and amplitudes can produce equal pitch perception. We found that the perceptually indistinguishable but physically different stimuli follow a common computational principle in mouse and human. It dictates that vibrotactile pitch perception is shifted with increases in amplitude toward the frequency of highest vibrotactile sensitivity. These findings suggest the existence of a fundamental relationship between the seemingly unrelated concepts of spectral sensitivity and pitch perception.</p> Animals Female Fingers / innervation Fingers / physiology Forelimb / innervation Forelimb / physiology Humans Male Mice Mice, Inbred C57BL Pitch Perception / physiology Sensory Thresholds / physiology Touch Perception / physiology Vibration Dewey 616.8 Swiss National Science Foundation Dissecting the neuronal circuit mechanisms underlying neuroprosthetic learning 184829 CH Projects 53 Département de neurosciences fondamentales 21A false 571 Groupe Huber Daniel (neurosciences fondamentales) 914 https://doi.org/10.26037/yareta:p73yr7n7bnfnbp6wrt355g5q5e Nature communications 12 1 cb86b991-173f-435f-81c4-30e8174e550e Article (Published version) Public Article-scientifique-from-crossref.pdf 1781342 application/pdf CC BY-4.0 6a757b17-b39b-4fa3-bdf2-7c2764731bc2 Supplemental data Public 41467_2021_25476_MOESM1_ESM.pdf 519803 application/pdf CC BY-4.0 4fdbe42b-0aeb-4fe4-adbc-56f44468581e Supplemental data Public 41467_2021_25476_MOESM4_ESM.xlsx 22644 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 58a8a91a2034d76f93858726d9ae50f87e04d6e0beb87188da3759c216c6cba4 d8be6583-dc94-44be-84f6-143702a1dba5 Appendix Public 41467_2021_25476_MOESM3_ESM.pdf 146668 application/pdf 90e21037a93f46fc8ee2e2033da6707d3feb340c7cda2069d397402ab6c959be openAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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A common computational principle for vibrotactile pitch perception in mouse and human	Nature communications			2021	234	312

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