Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles

Article Article scientifique Article Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles eng 2020 author Kilin Vasyl 848858 author Campargue Gabriel 861805 author Fureraj Ina 0000-0001-8875-6344 750321 author Sakong Sim 873250 author Sabri Tarek author Riporto Florian author Vieren Alice 930749 author Mugnier Yannick author Mas Christophe author Staedler Davide author Collins John Michael author Bonacina Luigi 0000-0003-0476-4473 632447 author Vogel Alfred author Capobianco John A. author Wolf Jean-Pierre 0000-0003-3729-958X 631266 10.1021/acsnano.9b08813 1936-086X https://pubs.acs.org/doi/10.1021/acsnano.9b08813 We introduce a nonlinear all-optical theranostics protocol based on the excitation wavelength decoupling between imaging and photoinduced damage of human cancer cells labeled by bismuth ferrite (BFO) harmonic nanoparticles (HNPs). To characterize the damage process, we rely on a scheme for in situ temperature monitoring based on upconversion nanoparticles: by spectrally resolving the emission of silica coated NaGdF4:Yb3+/Er3+ nanoparticles in close vicinity of a BFO HNP, we show that the photointeraction upon NIR-I excitation at high irradiance is associated with a temperature increase >100 °C. The observed laser–cell interaction implies a permanent change of the BFO nonlinear optical properties, which can be used as a proxy to read out the outcome of a theranostics procedure combining imaging at 980 nm and selective cell damage at 830 nm. The approach has potential applications to monitor and treat lesions within NIR light penetration depth in tissues. Photoinduced cell damage Harmonic generation Harmonic nanoparticles Upconversion nanoparticles Nanothermometry Dewey 500.2 27 Section de physique 13 false 676 Groupe Wolf ACS Nano 1410077a-9a5d-4b56-92b6-8946a589638d Article (Accepted version) Public acsnano.9b08813.pdf 978407 application/pdf Restricted 2021-04-20 openAccess Faculté des sciences / Section de physique

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Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles	ACS Nano			2020	456	494

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