Persistent symptoms after SARS-CoV-2 infection in children: a cross-sectional population-based serological study

Article Article scientifique Article Persistent symptoms after SARS-CoV-2 infection in children: a cross-sectional population-based serological study eng 2022-11-21 2022-11-21 author Dumont Roxane Dina Caroline 0000-0001-5910-9025 Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. 821316 author Nehme Mayssam 0000-0001-9189-6495 Division and Department of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. 840942 author Lorthe Elsa Louise Adèle Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. 416911 author De Mestral Carlos Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. author Richard Viviane Adissa Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. 899625 author Baysson Hélène 0000-0003-0916-6958 Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.,Department of Health and Community Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland. 927962 Hélène BAYSSON author Pennacchio Francesco Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. author Lamour Julien Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. author Semaani Claire Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. author Zaballa María-Eugenia Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. author Pullen Nick Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. author Perrin Anne 0000-0002-2023-3157 Division of General Pediatrics, Department of Woman, Child, and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland. author L'Huillier Arnaud 0000-0001-9230-7285 Division of General Pediatrics, Department of Woman, Child, and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland. 543058 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Posfay Barbe Klara Division of General Pediatrics, Department of Woman, Child, and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland. 39230 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Guessous Idris Division and Department of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.,Department of Health and Community Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland. 760565 Médecine de premier recours hospitalo-universitaire (MPRHU) author Stringhini Silvia 0000-0002-4387-8943 Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland silvia.stringhini@hcuge.ch.,Department of Health and Community Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.,University Center for General Medicine and Public Health, University of Lausanne, Lausanne, Switzerland. 830749 Médecine de premier recours hospitalo-universitaire (MPRHU) Specchio-COVID19 study group collaborator Chappuis François 34709 Département de santé et médecine communautaire (MECOM) collaborator Courvoisier Delphine 0000-0002-1956-2607 94475 Département de médecine (DEMED) collaborator Hurst Samia 0000-0002-1980-5226 84281 iEH2 (COETH) collaborator Eckerle Isabella Anne 894639 Département de médecine (DEMED) collaborator Flahaut Antoine 930124 collaborator Kaiser Laurent 28229 Département de médecine (DEMED) collaborator Kherad Omar 509928 Département de médecine (DEMED) collaborator Lescuyer Pierre 0000-0001-6986-8738 562350 collaborator Meyer Benjamin 0000-0003-0601-3550 915879 Département de pathologie et immunologie (PATIM) collaborator Pittet Didier 117792 Décanat et administration de la faculté de médecine (ADMED) collaborator Rinaldi Frédéric 877259 collaborator Rizzo Jessica 600380 collaborator Vuilleumier Nicolas 61406 Département de médecine (DEMED) collaborator Wisniak Ania 717179 ania Wisniak collaborator Yerly Ferrillo Sabine 23752 e063504 10.1136/bmjopen-2022-063504 36410813 2044-6055 PMC9679867 https://bmjopen.bmj.com/content/12/11/e063504.long Objectives: To estimate the prevalence of children and adolescents reporting persistent symptoms after SARS-CoV-2 infection. Design: A random sample of children and adolescents participated with their family members to a serological survey including a blood drawing for detecting antibodies targeting the SARS-CoV-2 nucleocapsid (N) protein and a questionnaire on COVID-19-related symptoms experienced since the beginning of the pandemic. Setting: The study took place in the canton of Geneva, Switzerland, between June and July 2021. Participant: 660 children aged between 2 and 17 years old. Primary and secondary outcome: The primary outcome was the persistence of symptoms beyond 4 weeks comparing seropositive and seronegative participants. The type of declared symptoms were also studied as well as associated risk factors. Results: Among seropositive children, the sex-adjusted and age-adjusted prevalence of symptoms lasting longer than 2 weeks was 18.3%, compared with 11.1% among seronegatives (adjusted prevalence difference (ΔaPrev)=7.2%, 95% CI: 1.5% to 13.0%). Among adolescents aged 12-17 years, we estimated the prevalence of experiencing symptoms lasting over 4 weeks to be 4.4% (ΔaPrev,95% CI: -3.8% to 13.6%), whereas no seropositive child aged 2-11 reported symptoms of this duration. The most frequently declared symptoms were fatigue, headache and loss of smell. Conclusions: We estimated the prevalence of experiencing persistent symptoms lasting over 4 weeks to be around 4% among adolescents, which represents a large absolute number, and should raise awareness and concern. We did not observe meaningful differences of persistent symptoms between seropositive and seronegative younger children, suggesting that they may be less affected than their older counterparts. Epidemiology Paediatric infectious disease & immunisation Public health Adolescent Child Humans Child, Preschool COVID-19 / epidemiology Cross-Sectional Studies SARS-CoV-2 Pandemics Research Design Dewey 174.957 Dewey 613 Dewey 618 69 Institut Ethique Histoire Humanités 22A6 58 Département de pédiatrie, gynécologie et obstétrique 223 219 Institut universitaire de médecine de famille et de l'enfance 22A93 false 453 Ethique biomédicale 783 1074 Groupe Klara Posfay-Barbe 515 Recherche en infectiologie pédiatrique et en pédiatrie générale 853 1255 Virus émergents 993 BMJ open 12 11 7fddf44e-75a9-4830-b349-2d24c71c0307 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 458337 application/pdf CC BY-NC 55045d881ec393a502887b7a7b8a7d0eb3bc386dad04416ef1e97d57c40a880d 77d348c5-d0b4-49bd-9d85-587503578ac0 Supplemental data Public bmjopen-2022-063504supp001_data_sup.pdf 423759 application/pdf dc65108c5c8acd5657cbdb02c919a193b845680794edaf4b8339d410af9ea564 openAccess Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut Ethique Histoire Humanités Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut de médecine de premier recours / Institut universitaire de médecine de famille et de l'enfance

Title	Published in	Year	Views	Downloads

Specchio-COVID19 cohort study: a longitudinal follow-up of SARS-CoV-2 serosurvey participants in the canton of Geneva, Switzerland	BMJ open	2022	238	100
Persistent symptoms after SARS-CoV-2 infection in children: a cross-sectional population-based serological study	BMJ open	2022	124	216

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