Mechanisms of senescence and anti-senescence strategies in the skin

Article Article scientifique Revue de la littérature Mechanisms of senescence and anti-senescence strategies in the skin eng 2024-08-23 2024-08-23 author Konstantinou Evangelia 0000-0001-6941-5552 Department of Medicine, University of Geneva, Rue Michel-Servet 1, CH-1206 Geneva, Switzerland. 967257 Département de médecine (DEMED) author Longange Mbutu Metondolo Eliane Bery Mireille Department of Medicine, University of Geneva, Rue Michel-Servet 1, CH-1206 Geneva, Switzerland. 928875 author Kaya Guerkan 0000-0003-4957-549X Department of Medicine, University of Geneva, Rue Michel-Servet 1, CH-1206 Geneva, Switzerland.,Departments of Dermatology and Clinical Pathology, Geneva University Hospitals, Rue Gabrielle Perret-Gentil 4, CH-1205 Geneva, Switzerland. 26603 Département de médecine (DEMED) 647 10.3390/biology13090647 39336075 2079-7737 PMC11428750 https://www.mdpi.com/2079-7737/13/9/647 The skin is the layer of tissue that covers the largest part of the body in vertebrates, and its main function is to act as a protective barrier against external environmental factors, such as microorganisms, ultraviolet light and mechanical damage. Due to its important function, investigating the factors that lead to skin aging and age-related diseases, as well as understanding the biology of this process, is of high importance. Indeed, it has been reported that several external and internal stressors contribute to skin aging, similar to the aging of other tissues. Moreover, during aging, senescent cells accumulate in the skin and express senescence-associated factors, which act in a paracrine manner on neighboring healthy cells and tissues. In this review, we will present the factors that lead to skin aging and cellular senescence, as well as ways to study senescence in vitro and in vivo. We will further discuss the adverse effects of the accumulation of chronic senescent cells and therapeutic agents and tools to selectively target and eliminate them. SASP Cellular senescence P16INK4a Senolytics Senomorphics Senotherapy Skin aging Dewey 616.07 Dewey 616 Louis-Jeantet Foundation ME11886 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 false 503 SERVICE DE PATHOLOGIE CLINIQUE 841 478 Vieillissement cutané 809 Biology 13 9 26494143-ad9b-4dcf-b6ca-ec29011ee6f5 Article (Published version) Public Article_scientifique_from_europePmc.pdf 1595728 application/pdf CC BY-4.0 6e745c57f3ca8bb9878da1ea067944e82b3416607307bca1914bc7c922573213 openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine

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Mechanisms of senescence and anti-senescence strategies in the skin	Biology			2024	140	261

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Longange Mbutu Metondolo, Eliane Bery Mireille