Dysfunctional temporal stages of eye-gaze perception in adults with ADHD: A high-density EEG study

Article Article scientifique Article Dysfunctional temporal stages of eye-gaze perception in adults with ADHD: A high-density EEG study eng 2022-05-12 2022-05 author Mauriello Cheyenne 925086 author Pham Eléonore Sibylle Minh Le 645607 author Kumar Samika 848067 author Piguet Camille Marie 0000-0003-4317-0918 541240 Camille Marie Nemitz author Deiber Marie-Pierre 130192 author Aubry Jean-Michel 32998 author Dayer Alexandre 84495 author Michel Christoph 91629 author Perroud Nader Ali 0000-0002-9282-9216 94458 author Berchio Cristina 801726 108351 10.1016/j.biopsycho.2022.108351 35568095 0301-0511 https://linkinghub.elsevier.com/retrieve/pii/S030105112200093X ADHD has been associated with social cognitive impairments across the lifespan, but no studies have specifically addressed the presence of abnormalities in eye-gaze processing in the adult brain. This study investigated the neural basis of eye-gaze perception in adults with ADHD using event-related potentials (ERP). Twenty-three ADHD and 23 controls performed a delayed face-matching task with neutral faces that had either direct or averted gaze. ERPs were classified using microstate analyses. ADHD and controls displayed similar P100 and N170 microstates. ADHD was associated with cluster abnormalities in the attention-sensitive P200 to direct gaze, and in the N250 related to facial recognition. For direct gaze, source localization revealed reduced activity in ADHD for the P200 in the left/midline cerebellum, as well as in a cingulate-occipital network at the N250. These results suggest brain impairments involving eye-gaze decoding in adults with ADHD, suggestive of neural signatures associated with this disorder in adulthood. ADHD ERP Eye-gaze Face perception Adult Attention Deficit Disorder with Hyperactivity Electroencephalography / methods Evoked Potentials Facial Expression Facial Recognition Fixation, Ocular Humans Visual Perception Dewey 616.89 Dewey 616.8 Swiss National Science Foundation NCCR SYNAPSY: The synaptic bases of mental diseases (phase II) CH Programmes Swiss National Science Foundation Investigating functional neural circuit vulnerability and biomarkers in high-risk offspring and normothymic bipolar disorder patients 32003B_156914 CH Project funding 60 Département de psychiatrie 225 53 Département de neurosciences fondamentales 21A false 417 Thérapeutiques des Troubles de l'Humeur et Anxieux 689 1342 Régulation des émotions : TDAH et trouble de la personnalité borderline 1028 1391 Régulation émotionnelle chez les adolescents et jeunes adultes 1042 535 Groupe Dayer Alexandre (Formation du circuit cortical) 875 1284 NCCR Synapsy Biological psychology 171 9a7551a2-38da-4f02-9ca9-451757fe190e Article (Published version) Public 1-s2.0-S030105112200093X-main.pdf 4485756 application/pdf CC BY-NC-ND-4.0 openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Dysfunctional temporal stages of eye-gaze perception in adults with ADHD: A high-density EEG study	Biological psychology			2022	238	320

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Mauriello, Cheyenne