Initial evidence of abnormal brain plasticity in anorexia nervosa: an ultra-high field study

Article Article scientifique Article Initial evidence of abnormal brain plasticity in anorexia nervosa: an ultra-high field study eng 2022-02-16 2022-02-16 author Pappaianni Edoardo 914178 author Borsarini Bianca 0009-0007-9331-6651 934855 author Doucet Gaelle E. author Hochman Ayelet author Frangou Sophia author Micali Nadia 877746 2589 10.1038/s41598-022-06113-x 35173174 2045-2322 PMC8850617 https://www.nature.com/articles/s41598-022-06113-x Anorexia Nervosa has been associated with white matter abnormalities implicating subcortical abnormal myelination. Extending these findings to intracortical myelin has been challenging but ultra-high field neuroimaging offers new methodological opportunities. To test the integrity of intracortical myelin in AN we used 7 T neuroimaging to acquire T1-weighted images optimized for intracortical myelin from seven females with AN (age range: 18–33) and 11 healthy females (age range: 23–32). Intracortical T 1 values (inverse index of myelin concentration) were extracted from 148 cortical regions at ten depth-levels across the cortical ribbon. Across all cortical regions, these levels were averaged to generate estimates of total intracortical myelin concentration and were clustered using principal component analyses into two clusters; the outer cluster comprised T 1 values across depth-levels ranging from the CSF boundary to the middle of the cortical regions and the inner cluster comprised T 1 values across depth-levels ranging from the middle of the cortical regions to the gray/white matter boundary. Individuals with AN exhibited higher T 1 values (i.e., decreased intracortical myelin concentration) in all three metrics. It remains to be established if these abnormalities result from undernutrition or specific lipid nutritional imbalances, or are trait markers; and whether they may contribute to neurobiological deficits seen in AN. Psychiatric disorders Magnetic resonance imaging Dewey 616.89 Dewey 618 60 Département de psychiatrie 225 58 Département de pédiatrie, gynécologie et obstétrique 223 false 1262 Troubles de l'alimentation, des comportements alimentaires et autres troubles associés 996 Scientific reports 12 1 6c57838b-5e1a-4e64-b876-fcb892e97d6b Article (Published version) Public Article-scientifique-from-unpaywall.pdf 2180265 application/pdf CC BY-4.0 8f5aed8a-d4fd-4af3-88ae-e9d0eb28fcc9 Appendix Public 41598_2022_6113_MOESM1_ESM.docx 196449 application/vnd.openxmlformats-officedocument.wordprocessingml.document openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Initial evidence of abnormal brain plasticity in anorexia nervosa: an ultra-high field study	Scientific reports			2022	249	289

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