Functional and computational genomics reveal unprecedented flexibility in stage-specific Toxoplasma metabolism

Article Article scientifique Article Functional and computational genomics reveal unprecedented flexibility in stage-specific Toxoplasma metabolism eng 2020 author Krishnan Aarti 831441 author Kloehn Joachim 869011 author Lunghi Matteo 868427 author Chiappino-Pepe Anush author Waldman Benjamin S. author Nicolas Damien 909404 author Varesio Emmanuel 30230 author Hehl Adrian author Lourido Sebastian author Hatzimanikatis Vassily author Soldati-Favre Dominique 0000-0003-4156-2109 135114 10.1016/j.chom.2020.01.002 31991093 1931-3128 https://linkinghub.elsevier.com/retrieve/pii/S193131282030041X CRISPR-Cas9 screen Toxoplasma gondii Bradyzoite Fatty acid biosynthesis Heme biosynthesis Metabolic network Metabolism Synthetic lethality Tachyzoite Vitamin B6 Dewey 615 Dewey 616 Swiss National Science Foundation Cyst wall formation: a persistent challenge in Toxoplasmosis 160702 CH Programmes Swiss National Science Foundation odorant-induced transcriptional downregulation: from mechanisms to olfactory coding 189153 CH Project funding Swiss National Science Foundation 157303 CH European Commission Molecular Basis of Toxoplasma gondii Encystation and Persistence 695596 ToxoPersist EU H2020 31 Section des sciences pharmaceutiques 17 54 Département de microbiologie et médecine moléculaire 21B false 443 Biologie d'un parasite intracellulaire obligatoire 773 Cell Host & Microbe b42bcd37-d07e-4cba-b794-f334c66d5609 Article (Accepted version) Public Krishnan_CHM_2020-1.pdf 2630806 application/pdf Restricted 2021-01-30 eed311f4-fa5c-414b-8a75-3b1592556f50 Article (Published version) Restricted 1-s2.0-S193131282030041X-mmc9.pdf 24426725 application/pdf 1ca7cb24-f72e-486c-a260-922800fda58f Supplemental data Restricted 1-s2.0-S193131282030041X-mmc2.xlsx 273656 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 9155af86-3eb9-4b29-a49e-a3bb71e1eb5d Supplemental data Restricted 1-s2.0-S193131282030041X-mmc3.xlsx 805406 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 350f0afd-0251-4847-9db0-88824079bac2 Supplemental data Restricted 1-s2.0-S193131282030041X-mmc4.xlsx 46774 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 00337cca-9548-484b-a8b2-14970b68a697 Supplemental data Restricted 1-s2.0-S193131282030041X-mmc5.xlsx 1256186 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 26f36b14-1485-42aa-945b-c905fbe3f34e Supplemental data Restricted 1-s2.0-S193131282030041X-mmc6.xlsx 13754 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 88b480e4-f690-43b8-9b9d-946d3e764af5 Supplemental data Restricted 1-s2.0-S193131282030041X-mmc7.xlsx 1682907 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet openAccess Faculté des sciences / Section des sciences pharmaceutiques Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire

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Functional and computational genomics reveal unprecedented flexibility in stage-specific Toxoplasma metabolism	Cell Host & Microbe			2020	573	310

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Nicolas, Damien