Hyperthermia and radiotherapy : physiological basis for a synergistic effect

Article Article scientifique Revue de la littérature Hyperthermia and radiotherapy : physiological basis for a synergistic effect eng 2024-08-06 2024 author Righini Michael Francis Faculty of Medicine, University of Geneva (UNIGE), Geneva, Switzerland. 907050 author Durham Faivre André-Dante Faculty of Medicine, University of Geneva (UNIGE), Geneva, Switzerland.,Department of Radiation Oncology, Geneva University Hospitals (HUG), Geneva, Switzerland. 976635 author Tsoutsou Pelagia Faculty of Medicine, University of Geneva (UNIGE), Geneva, Switzerland.,Department of Radiation Oncology, Geneva University Hospitals (HUG), Geneva, Switzerland. 927344 Département de radiologie et informatique médicale (RADIO) 1428065 10.3389/fonc.2024.1428065 39165690 2234-943X PMC11333208 https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1428065/full In cancer treatment, mild hyperthermia (HT) represents an old, but recently revived opportunity to increase the efficacy of radiotherapy (RT) without increasing side effects, thereby widening the therapeutic window. HT disrupts cellular homeostasis by acting on multiple targets, and its combination with RT produces synergistic antitumoral effects on specific pathophysiological mechanisms, associated to DNA damage and repair, hypoxia, stemness and immunostimulation. HT is furthermore associated to direct tumor cell kill, particularly in higher temperature levels. A phenomenon of temporary resistance to heat, known as thermotolerance, follows each HT session. Cancer treatment requires innovative concepts and combinations to be tested but, for a meaningful development of clinical trials, the understanding of the underlying mechanisms of the tested modalities is essential. In this mini-review, we aimed to describe the synergistic effects of the combination of HT with RT as well as the phenomena of thermal shock and thermotolerance, in order to stimulate clinicians in new, clinically relevant concepts and combinations, which become particularly relevant in the era of technological advents in both modalities but also cancer immunotherapy. DNA-repair Cancer biology Hyperthermia Hypoxia Immunotherapy Radiotherapy Thermotolerance Tumor microenvironment Dewey 616.0757 62 Département de radiologie et informatique médicale 227 false Frontiers in oncology 14 fd08ffe8-cdb7-48b3-91f3-fce6aa8a64fe Article (Published version) Public Article_scientifique_from_unpaywall.pdf 772623 application/pdf CC BY-4.0 993c6a1c6aa9c15f8bec0d8e5a16ff054b3d8305f2ad31c82b9d46cac69f889b openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Hyperthermia and radiotherapy : physiological basis for a synergistic effect	Frontiers in oncology			2024	49	201

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Righini, Michael Francis