Regulatory cells in the skin: Pathophysiologic role and potential targets for anti-inflammatory therapies

Article Article scientifique Revue de la littérature Regulatory cells in the skin: Pathophysiologic role and potential targets for anti-inflammatory therapies eng 2019 author Uttarkar Sagar 906070 author Brembilla Nicolo 703016 author Boehncke Wolf-Henning 779122 1302-1310 10.1016/j.jaci.2018.12.1011 30664891 0091-6749 https://www.sciencedirect.com/science/article/pii/S0091674919300363 Inflammation is a fundamental defense mechanism to protect the body from danger, which becomes potentially harmful if it turns chronic. Therapeutic strategies aimed at specifically blocking proinflammatory signals, particularly cytokines, such as IL-4, IL-6, IL-13, IL-17A, or TNF-α, have substantially improved our ability to effectively and safely treat chronic inflammatory diseases. Much less effort has been made to better understand the role of potential anti-inflammatory mechanisms. Here we summarize the current understanding of regulatory cell populations in the context of chronic inflammation, namely macrophages, Langerhans cells, myeloid-derived suppressor cells, and regulatory T and B lymphocytes. Emphasis is given to the skin because many different immune-related diseases occur in the skin. Development, phenotype, function, and evidence for their role in animal models of inflammation, as well as in the corresponding human diseases, are described. Finally, the feasibility of using regulatory cells as targets for potentially disease-modifying therapeutic strategies is discussed. Animals Anti-Inflammatory Agents/pharmacology B-Lymphocytes/immunology Humans Inflammation/immunology/pathology Langerhans Cells/immunology Macrophages/immunology Myeloid-Derived Suppressor Cells/immunology Skin/immunology/pathology T-Lymphocytes, Regulatory/immunology Dewey 616 Dewey 616.07 Swiss National Science Foundation Studying how chronic inflammation alters epidermal homeostasis using psoriasis as a model disease 175470 CH Project funding 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 false 576 Inflammation cutanée 919 Journal of Allergy and Clinical Immunology 143 4 edee40d0-fa72-44e5-a991-e18592fcb44e Article (Published version) Restricted 30664891.pdf 989740 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine

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Regulatory cells in the skin: Pathophysiologic role and potential targets for anti-inflammatory therapies	Journal of Allergy and Clinical Immunology			2019	273	0

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Uttarkar, Sagar