Vaccine Immunity Against Pneumococcus in Children With Sickle Cell Disease : A Retrospective Single-center Study

Article Article scientifique Article Vaccine Immunity Against Pneumococcus in Children With Sickle Cell Disease : A Retrospective Single-center Study eng 2025-08-29 2026-01-01 author Noble Clara Gabrielle Madeleine 0009-0002-1828-2686 From the Faculty of Medicine.,Department of Pediatrics, Gynecology and Obstetrics, Research Platform of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland. 905957 author Gualtieri Renato 0000-0001-8164-7284 Department of Pediatrics, Gynecology and Obstetrics, Research Platform of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.,Department Women-Mother-Child, Pediatrics Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. 974851 author Mattiello Veneranda Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics, Unit of Hematology and Oncology. 766851 author Cimasoni Laurent Uberto Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics, Unit of Hematology and Oncology. 134791 author Blanchard Rohner Géraldine 0000-0002-9974-2172 Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics, Unit of Immunology, Vaccinology, and Rheumatology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. 518713 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) 68-73 10.1097/inf.0000000000004947 40924709 0891-3668 PMC12688463 Background and aims: Sickle cell disease (SCD) patients are at a higher risk of pneumococcal invasive diseases. Vaccination is the central strategy for protecting these children, along with penicillin prophylaxis. However, it is unclear how often these children should be revaccinated with pneumococcal vaccines. This retrospective study aimed to describe the pneumococcal vaccination status of children with SCD in a high-income country with access to vaccines, to see if the national vaccination guidelines are followed and effective at inducing good vaccine seroprotection. We also wanted to assess the longitudinal vaccine immunity and the effect of booster doses on vaccine seroprotection. Methods: Electronic medical records of 42 children with SCD diagnosed between 2009 and 2023 were retrospectively reviewed. Clinical demographic data and pneumococcal serologies were analyzed. Results: Of the 42 patients included in the study, 34 (81%) had available vaccine records. All of these patients had completed the age-appropriate vaccination schedule. Among them, 15 (44%) had received at least 1 booster dose, with a mean age of 3.47 years at the time of the booster. A Kaplan-Meier analysis revealed a significant decline in seroprotection after the age of 5 years following completion of the vaccination series. Conclusions: Our findings suggest that a booster vaccination may be necessary 5 years after the completion of the primary pneumococcal vaccination series. Further large-scale prospective studies are required to better define the optimal frequency of booster doses throughout life and to identify individual factors that contribute to the loss of serological protection. Pneumococcus Serology Sickle cell Vaccines Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 564 Oncologie et hématologie pédiatriques 907 515 Recherche en infectiologie pédiatrique et en pédiatrie générale 853 The Pediatric infectious disease journal 45 1 ab36742c-b15c-4a7d-8256-1b8658a32fce Article (Published version) Public vaccine_immunity_against_pneumococc.pdf 970456 application/pdf CC BY-4.0 8c65f8c977502ab1add0c9781dac9ac72cff250bbca33e763a3c55889a42a9a2 openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Vaccine Immunity Against Pneumococcus in Children With Sickle Cell Disease : A Retrospective Single-center Study	The Pediatric infectious disease journal			2026	12	39

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Noble, Clara Gabrielle Madeleine

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