Experimentally-evidenced personality alterations following meningioma resection: A case report

Article Article scientifique Rapport de cas Experimentally-evidenced personality alterations following meningioma resection: A case report eng 2023-08-25 2023-11 author Orepic Pavo Laboratory of Cognitive Neuroscience, NeuroX Institute and Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland. 965457 author Iannotti Giannina Rita Functional Brain Mapping Lab, Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland; Department of Neurosurgery, Geneva University Medical Center & Faculty of Medicine, University of Geneva, Geneva, Switzerland. 791431 Centre d'imagerie bio-médicale (CIBM) author Haemmerli Julien 0000-0001-5998-8541 Department of Neurosurgery, Geneva University Medical Center & Faculty of Medicine, University of Geneva, Geneva, Switzerland. 659636 author Goga Cristina Department of Neurosurgery, Geneva University Medical Center & Faculty of Medicine, University of Geneva, Geneva, Switzerland. 903082 author Park Hyeong-Dong Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan; Brain and Consciousness Research Centre, Shuang-Ho Hospital, New Taipei City, Taiwan. author Betka Sophie Laboratory of Cognitive Neuroscience, NeuroX Institute and Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland. 935330 Service de Soutien à la Recherche (SSR) author Blanke Olaf Laboratory of Cognitive Neuroscience, NeuroX Institute and Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland; Faculty of Medicine, University of Geneva, Geneva, Switzerland. 107390 Département des neurosciences cliniques (OTONO) author Michel Christoph Functional Brain Mapping Lab, Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland; Center for Biomedical Imaging (CIBM), Lausanne and Geneva, Switzerland. 91629 Décanat et administration de la faculté de médecine (ADMED) author Bondolfi Guido Department of Psychiatry, Geneva University Medical Center & Faculty of Medicine, University of Geneva, Geneva, Switzerland. 135439 Décanat et administration de la faculté de médecine (ADMED) author Schaller Karl Lothard Department of Neurosurgery, Geneva University Medical Center & Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address: karl.schaller@unige.ch. 658606 Département des neurosciences cliniques (OTONO) 157-166 10.1016/j.cortex.2023.08.006 37716111 0010-9452 https://www.sciencedirect.com/science/article/pii/S0010945223002046 Personality changes following neurosurgical procedures remain poorly understood and pose a major concern for patients, rendering a strong need for predictive biomarkers. Here we report a case of a female patient in her 40s who underwent resection of a large sagittal sinus meningioma with bilateral extension, including resection and ligation of the superior sagittal sinus, that resulted in borderline personality disorder. Importantly, we captured clinically-observed personality changes in a series of experiments assessing self-other voice discrimination, one of the experimental markers for self-consciousness. In all experiments, the patient consistently confused self- and other voices - i.e., she misattributed other-voice stimuli to herself and self-voice stimuli to others. Moreover, the electroencephalogram (EEG) microstate, that was in healthy participants observed when hearing their own voice, in this patient occurred for other-voice stimuli. We hypothesize that the patient's personality alterations resulted from a gradual development of a venous collateral hemodynamic network that impacted venous drainage of brain areas associated with self-consciousness. In addition, resection and ligation of the superior sagittal sinus significantly aggravated personality alterations through postoperative decompensation of a direct frontal lobe compression. Experimentally mirroring clinical observations, these findings are of high relevance for developing biomarkers of post-surgical personality alterations. Borderline personality disorder EEG microstates Meningioma resection Post-surgical personality alterations Sagittal sinus meningioma Self-other voice discrimination Dewey 616.8 Dewey 616.89 Swiss National Science Foundation Mapping the brain networks of the bodily and cognitive self for the prediction of personality deficits following brain surgery 182497 CH Projects Pictet Foundation Swiss National Science Foundation Capturing thoughts: the neural correlates of spontaneous mentation 184677 CH Projects Fondazione Teofilo Rossi di Montelera e di Premuda 61 Département des neurosciences cliniques 226 53 Département de neurosciences fondamentales 21A 60 Département de psychiatrie 225 false 418 Médecine psychosomatique, neurosciences cliniques et mindfulness 690 513 Groupe Schaller Karl Lothard (neurochirurgie) 851 118 Organisation et plasticité des réseaux neuronaux cérébraux 148 426 BLANKE OLAF 699 523 CIBM 863 Cortex 168 979379a0-8ac6-42e2-9dbf-419d2f026d4b Article (Published version) Public 1-s2.0-S0010945223002046-main.pdf 1106432 application/pdf CC BY-4.0 a494b6fd71e6afef55692cebb9fcd380fff1049b14ea24ce672f15dcd2b593a6 9ca4b875-64be-4d61-87d8-9f203bbf3591 Supplemental data Public 1-s2.0-S0010945223002046-mmc1.docx 5914626 application/vnd.openxmlformats-officedocument.wordprocessingml.document ed1cd8be2222a83504137b8db9ee1dad470f2fdbbc7c9cbd22e169660220f08e openAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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