Spot urine samples to estimate 24-hour urinary calcium excretion in school-age children

Article Article scientifique Article Spot urine samples to estimate 24-hour urinary calcium excretion in school-age children eng 2020 author Paccaud Yan 901069 author Rios-Leyvraz Magali author Bochud Murielle author Tabin René Roger 58962 author Genin Bernard 34808 author Russo Michel author Rossier Michel 22435 author Bovet Pascal author Chiolero Arnaud author Parvex Paloma Maria 36046 1673-1681 10.1007/s00431-020-03662-z 32388721 0340-6199 Urinary calcium/creatinine ratio (UCa/Cr) on a single spot urine sample is frequently used in children to evaluate calciuria, but its accuracy to estimate 24-h urinary calcium excretion (24hUCa) has not been properly assessed. We analyzed the correlation between UCa/Cr in various spot samples and 24hUCa among healthy children. A 24-h urine specimen and three spot urine samples (evening, first, and second morning) were collected in a convenience sample of children aged 6 to 16 years (n = 101). Measured 24hUCa was compared with UCa/Cr in each of the three spot samples. The ability of UCa/Cr to discriminate between children with and without hypercalciuria (calciuria > 4 mg/kg/24 h, 1 mmol/kg/24 h) and optimal timing of the spot sample were determined. Eighty-five children completed an adequate 24-h urine collection. Pearson correlation coefficients between the UCa/Cr on the spot sample and 24hUCa were 0.64, 0.71, and 0.52 for the evening, first, and second morning spot samples, respectively. Areas under the ROC curve were 0.90, 0.82, and 0.75, respectively, for the corresponding spot samples.Conclusion: The relatively strong correlation between 24hUCa and UCa/Cr in evening and first morning spot urine samples suggests that these spots could be preferred in clinical practice.Trial registration: ClinicalTrials.gov , NCT02900261, date of trial registration 14 September 2016. What is Known: •Urinary calcium/creatinine ratio on a single spot urine sample is frequently used as a proxy for 24-h urinary calcium excretion. •Correlation of these indicators, including the best timing for spot urine sampling, has not been properly assessed. What is New: •Relatively strong correlations were found between the calcium/creatinine ratio on a single spot urine sample and 24-h urinary calcium excretion in healthy children. •Evening and first morning spot samples had the highest correlation. Calcium Calcium Dietary Child Creatinine Humans Schools Urine Specimen Collection Dewey 616 Dewey 618 56 Département de médecine 221 58 Département de pédiatrie, gynécologie et obstétrique 223 false European Journal of Pediatrics 179 11 3f865b07-0c6c-4bdb-9b94-8e51397689e1 Article (Published version) Restricted Paccaud2020_Article_SpotUrineSamplesToEstimate24-h.pdf 823860 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Title	Published in	Year	Views	Downloads

Spot urine samples to estimate 24-hour urinary calcium excretion in school-age children	European Journal of Pediatrics	2020	184	0
Spots urinaires pour l'évaluation de la calciurie de 24 heures chez les enfants d'âge scolaire		2020	1,934	1,765

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Paccaud, Yan