Gabapentinoids: The rise of a new misuse epidemics?

Article Article scientifique Article Gabapentinoids: The rise of a new misuse epidemics? eng 2021-08-28 2021-11 author Hofmann Michel 898481 author Besson Marie 87576 114193 10.1016/j.psychres.2021.114193 34534775 0165-1781 https://www.sciencedirect.com/science/article/pii/S0165178121004893 Gabapentinoids and opioids have in common that they are used in medicine in the treatment of pain, and by addicts in recreational use. In recent years, in the context of the "opioid epidemics", gabapentinoids, which had a reputation for low risk of abuse, have been increasingly prescribed. This was accompanied by increasingly frequent abuses, the patients most at risk being those suffering from opiate addiction. However, gabapentinoids increase the risks associated with opioids or other sedatives, due to a synergy of central depressant effects. This leads to reconsider the framework of their prescription and the management of chronic pain. Abuse Gabapentine Pregabaline Analgesics, Opioid / adverse effects Chronic Pain / drug therapy Epidemics Humans Opioid-Related Disorders / drug therapy Opioid-Related Disorders / epidemiology Prescription Drug Misuse Risk Dewey 616.89 Dewey 617 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 60 Département de psychiatrie 225 false 302 Groupe Desmeules Jules (pharmacologie/toxicologie) 567 Psychiatry research 305 66cccd5f-36b1-433d-9025-1d6dd64eaf0d Article (Published version) Public 1-s2.0-S0165178121004893-main.pdf 371501 application/pdf CC BY-4.0 openAccess Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Gabapentinoids: The rise of a new misuse epidemics?	Psychiatry research			2021	245	571

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Hofmann, Michel