Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients

Article Article scientifique Article Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients eng 2021-03-15 2021-03-15 author Demené Charlie author Robin Justine 893485 author Dizeux Alexandre author Heiles Baptiste 0000-0001-9254-1741 author Pernot Mathieu 0000-0001-6713-4642 author Tanter Mickael 0000-0001-7739-8051 author Perren Fabienne 0000-0001-8166-2193 628927 219-228 10.1038/s41551-021-00697-x 33723412 2157-846X PMC7610356 http://www.nature.com/articles/s41551-021-00697-x Changes in cerebral blood flow are associated with stroke, aneurysms, vascular cognitive impairment, neurodegenerative diseases and other pathologies. Brain angiograms, typically performed via computed tomography or magnetic resonance imaging, are limited to millimetre-scale resolution and are insensitive to blood-flow dynamics. Here we show that ultrafast ultrasound localization microscopy of intravenously injected microbubbles enables transcranial imaging of deep vasculature in the adult human brain at microscopic resolution and the quantification of haemodynamic parameters. Adaptive speckle tracking to correct for micrometric brain-motion artefacts and ultrasonic-wave aberrations induced during transcranial propagation allowed us to map the vascular network of tangled arteries to functionally characterize blood-flow dynamics at a resolution of up to 25 μm and to detect blood vortices in a small deep-seated aneurysm in a patient. Ultrafast ultrasound localization microscopy may facilitate the understanding of brain haemodynamics and of how vascular abnormalities in the brain are related to neurological pathologies. Arteries / pathology Brain / pathology Cerebrovascular Circulation / physiology Humans Microbubbles Microscopy / methods Motion Ultrasonography / methods Dewey 616.8 European Commission A new neuroimaging modality: from bench to bedside 339244 FUSIMAGINE EU FP7 Swiss National Science Foundation Assessment of the risk of rupture of intracranial aneurysms by ultrasound CR32I3_159654 CH Project funding 61 Département des neurosciences cliniques 226 false https://doi.org/10.5281/zenodo.4048550 Nature biomedical engineering 5 3 6c8c8ff3-dfd0-4098-b759-91b337ca6d17 Article (Accepted version) Restricted Perren Nature BME 2021.pdf 3168033 application/pdf CC BY 7544166d-db0f-4fd2-a6a1-3264a22d45f2 Appendix Public 41551_2021_697_MOESM1_ESM.pdf 1286370 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

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Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients	Nature biomedical engineering			2021	340	17

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Robin, Justine