Cytokine Release Syndrome: Dissecting Immune Responses and Exploring Novel Anti-cytokine Strategies in Syngeneic Mouse Models

Diplôme Thèse Cytokine Release Syndrome: Dissecting Immune Responses and Exploring Novel Anti-cytokine Strategies in Syngeneic Mouse Models eng 2021-10-01 2021-12-16 author Nouveau Lise Gilberte Francine 889198 director Ferlin Walter director Martinou Jean-Claude 27293 10.13097/archive-ouverte/unige:163854 urn:nbn:ch:unige-1638548 Sc. Vie 123 <p>The aberrant release of inflammatory mediators often referred to as a cytokine storm or cytokine release syndrome (CRS), is a common and sometimes fatal complication in acute infectious diseases including Ebola, dengue, COVID-19 and influenza. Fatal CRS occurrences have also plagued the development of highly promising cancer therapies based on T cell engagers and chimeric antigen receptor T cells. CRS is intimately linked with excessive cytokine release resulting in a systemic inflammatory response leading to multiple organ failure. CRS in patients is characterized by high fever, hypotension, hypoxia, and/or multiorgan toxicity. Global immunosuppression or immunosuppressants may control some of these toxicities. However, these therapeutic approaches have demonstrated partial efficacy and can block T cell activation, abrogating clinical benefit which is a concern especially in the context of immunotherapy. Therefore, a better understanding of the mechanisms underpinning the cytokine storm is critically needed and may help in early management of CRS.</p> Dewey 570 43 Département de biologie moléculaire 161 false 3ea000bf-8024-446e-ac3d-41c6089d8a2b Thesis Public Thesis-Nouveau-Lise-2021-final.pdf 11390422 application/pdf ed7fa5ba-f4ad-47d0-8ed8-260651a12400 Imprimatur Public 123 -IMP- NOUVEAU Lise-final.pdf 64186 application/pdf openAccess Faculté des sciences / Section de biologie / Département de biologie moléculaire

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Cytokine Release Syndrome: Dissecting Immune Responses and Exploring Novel Anti-cytokine Strategies in Syngeneic Mouse Models				2021	349	379

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