Pharmacological and non-pharmacological approaches to temporomandibular disorder chronic pain : a narrative review

Article Article scientifique Revue de la littérature Pharmacological and non-pharmacological approaches to temporomandibular disorder chronic pain : a narrative review eng 2025-05-08 2025-05 author Jogna Fanny Division of General Internal Medicine, Department of Medicine, University Hospitals of Geneva, Geneva, Switzerland. author Gränicher Adriana Division of General Internal Medicine, Department of Medicine, University Hospitals of Geneva, Geneva, Switzerland. 752603 author Rey-Millet Quentin Division of Anesthesiology, Department of Acute Medicine, University Hospitals of Geneva, Geneva, Switzerland. 802427 author Groz Alexandra Health Care Directorate, Geneva University Hospital, University Hospitals of Geneva, Geneva, Switzerland.,Multidisciplinary Center of Integrative Medicine, University Hospitals of Geneva, Geneva, Switzerland. 889082 author De Grasset Jehanne Orianne Multidisciplinary Center of Integrative Medicine, University Hospitals of Geneva, Geneva, Switzerland. 768538 author Stollar Fabiola 0000-0003-0895-2025 Multidisciplinary Center of Integrative Medicine, University Hospitals of Geneva, Geneva, Switzerland.,Division of General Pediatrics, Department of Pediatrics, Gynecology & Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.,Faculty of Medicine, University of Geneva, Geneva, Switzerland. 780318 author Coen Matteo 0000-0002-6156-1691 Division of General Internal Medicine, Department of Medicine, University Hospitals of Geneva, Geneva, Switzerland.,Multidisciplinary Center of Integrative Medicine, University Hospitals of Geneva, Geneva, Switzerland.,Unit of Research and Development in Medical Education, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 601519 Département de médecine (DEMED) author Faivre Anna 0000-0002-1752-7533 Division of General Internal Medicine, Department of Medicine, University Hospitals of Geneva, Geneva, Switzerland. 801532 285-296 10.1080/17581869.2025.2502311 40338653 1758-1869 PMC12118397 https://www.tandfonline.com/doi/full/10.1080/17581869.2025.2502311 Temporomandibular disorders (TMD) involve the temporomandibular joint and related structures, causing chronic pain, impaired jaw function, and reduced quality of life. TMD has multifactorial origins, including mechanical, neuromuscular, and inflammatory factors. Chronic TMD pain is difficult to manage due to its complex pathophysiology and the limited long-term effectiveness of existing treatments. A combination of pharmacological and non-pharmacological strategies is essential for optimal pain management. This narrative review provides an integrative overview of current treatments for TMD-associated chronic pain. Pharmacological options discussed include analgesics, muscle relaxants, antidepressants, anticonvulsants, and botulinum toxin injections. Non-pharmacological strategies include physical therapy, cognitive-behavioral therapy, acupuncture, and lifestyle modifications. A comprehensive literature search was conducted using PubMed, Embase.com, Cochrane, and Evidence Alerts databases through October 2024. We focused on original research articles, randomized controlled trials, narrative and systematic reviews, and meta-analyses. Effective management of chronic TMD pain requires a multidisciplinary approach tailored to individual needs. Evidence supports the integration of physical and psychological therapies into treatment plans. Future research should aim to develop targeted interventions that address underlying mechanisms of TMD pain and evaluate the long-term outcomes of noninvasive therapies. Temporomandibular disorders Chronic pain Complementary therapy Integrative medicine Nociceptive pain Pain management Pharmacology Dewey 610/370 Dewey 616 Dewey 617 Dewey 618 56 Département de médecine 221 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 58 Département de pédiatrie, gynécologie et obstétrique 223 48 Unité de développement et de recherche en éducation médicale 204 false 436 Médecine palliative 709 Pain management 15 5 84f3ce0d-1ed6-4d4a-9961-0450f28eac4d Article (Published version) Public Pharmacological_and_non-pharmacolog.pdf 588672 application/pdf CC BY-NC-ND-4.0 12e418c94154d9e85c0b3e6e032fb2bd1843a112a172753a6244e9643d7ac1b5 25baafef-0411-4283-a379-efc87b0a8e75 Supplemental data Public ipmt_a_2502311_sm0834.docx 55319 application/vnd.openxmlformats-officedocument.wordprocessingml.document 01eac5ea18dfda17a9d51877b4d26a43b9a33f7f9b38f838d87965ab8a4f82ad b76bfbe7-0365-408c-9a07-984a941b95df Supplemental data Public ipmt_a_2502311_sm0836.docx 39650 application/vnd.openxmlformats-officedocument.wordprocessingml.document c38a1b8dd734e0abd62876aed2451540bc2fd135f444bdc4aec41d7b8ac802c5 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Unité de développement et de recherche en éducation médicale

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Pharmacological and non-pharmacological approaches to temporomandibular disorder chronic pain : a narrative review	Pain management			2025	53	552

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Groz, Alexandra