Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating

Article Article scientifique Article Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating eng 2006 author Nguyen Cung An 88830 author Niamien Konan-Kouakou Yvette author Allémann Eric 0000-0002-6598-9521 26730 author Doelker Eric 25151 author Quintanar Guerrero David 97620 author Fessi Hatem author Gurny Robert 24779 54-60 10.1208/pt070363 1530-9932 http://www.springerlink.com/index/10.1208/pt070363 The aim of the present study was to prepare surfactant-free pseudolatexes of various methacrylic acid copolymers. These aqueous colloidal dispersions of polymeric materials for oral administration are intended for film coating of solid dosage forms or for direct manufacturing of manoparticles. Nanoparticulate dispersions were produced by an emulsification-diffusion method involving the use of partially water-miscible solvents and the mutual saturation of the aqueous and organic phases prior to the emulsification in order to reduce the initial thermodynamic instability of the emulsion. Because of the self-emulsifying properties of the methacrylic acid copolymers, it was possible to prepare aqueous dispersions of colloidal size containing up to 30% wt/vol of Eudragit RL, RS, and E using 2-butanone or methyl acetate as partially water-miscible solvents, but without any surfactant. However, in the case of the cationic Eudragit E, protonation of the tertiary amine groups by acidification of the aqueous phase was necessary to improve the emulsion stability in the absence of surfactant and subsequently to prevent droplet coalescence during evaporation. In addition, a pseudolatex of Eudragit E was used to validate the coating properties of the formulation for solid dosage forms. Film-coated tablets of quinidine sulfate showed a transparent glossy continuous film that was firmly attached to the tablet. The dissolution profile of quinidine sulfate from the tablets coated with the Eudragit E pseudolatex was comparable to that of tablets coated with an acetonic solution of Eudragit E. Furthermore, both types of coating ensured similar taste masking. The emulsification-evaporation method used was shown to be appropriate for the preparation of surfactant-free colloidal dispersions of the 3 types of preformed methacrylic acid copolymers; the dispersions can subsequently be used for film coating of solid dosage forms. Pseudolatex Methacrylic acid copolymers Eudragit Emulsification-diffusion method Nanoparticles Film coating Quinidine sulfate Dewey 615 31 Section des sciences pharmaceutiques 17 false 883 Technologie pharmaceutique AAPS PharmSciTech 7 3 718bb7b9-4d2a-40c3-a0aa-491a901e1d66 Article (Published version) Public C.An.Nguyen.pdf 237952 application/pdf openAccess Faculté des sciences / Section des sciences pharmaceutiques

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Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating	AAPS PharmSciTech			2006	589	244

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Nguyen, Cung An