Comparison of tissue tropism and host response to enteric and respiratory enteroviruses

Article Article scientifique Article Comparison of tissue tropism and host response to enteric and respiratory enteroviruses eng 2022-07-05 2022-07 author Cordeiro Filipe Inès 884452 author Tee Han Kang 952792 author Prados Julien 0000-0002-8546-241X 561771 author Piuz Isabelle 22086 author Constant Samuel author Huang Song author Tapparel Caroline 0000-0002-0411-6567 27039 e1010632 10.1371/journal.ppat.1010632 35789345 1553-7366 PMC9286751 Enteroviruses (EVs) are among the most prevalent viruses worldwide. They are characterized by a high genetic and phenotypic diversity, being able to cause a plethora of symptoms. EV-D68, a respiratory EV, and EV-D94, an enteric EV, represent an interesting paradigm of EV tropism heterogeneity. They belong to the same species, but display distinct phenotypic characteristics and in vivo tropism. Here, we used these two viruses as well as relevant 3D respiratory, intestinal and neural tissue culture models, to highlight key distinctive features of enteric and respiratory EVs. We emphasize the critical role of temperature in restricting EV-D68 tissue tropism. Using transcriptomic analysis, we underscore fundamental differences between intestinal and respiratory tissues, both in the steady-state and in response to infection. Intestinal tissues present higher cell proliferation rate and are more immunotolerant than respiratory tissues. Importantly, we highlight the different strategies applied by EV-D94 and EV-D68 towards the host antiviral response of intestinal and respiratory tissues. EV-D68 strongly activates antiviral pathways while EV-D94, on the contrary, barely induces any host defense mechanisms. In summary, our study provides an insightful characterization of the differential pathogenesis of EV-D68 and EV-D94 and the interplay with their main target tissues. Antigens, Viral Antiviral Agents Enterovirus Enterovirus D, Human / physiology Enterovirus Infections Humans Respiratory Tract Infections Tropism Dewey 616 Swiss National Science Foundation Factors modulating rhinovirus and enterovirus pathogenicity 310030_184777 CH Project funding 54 Département de microbiologie et médecine moléculaire 21B false 931 Identification des facteurs clés impliqués dans la pathogénèse des rhinovirus et entérovirus 953 48a82112-9f30-4dde-a32a-47c02fceac29 Bioinformatics Support Platform 0a6434c9-7972-44ea-8708-82e501660dc7 Biomedical Data Science Facility https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE184488 PLOS pathogens 18 7 d935cb96-f61b-4d5a-b3ce-28efe604d8af Article (Published version) Public Article-scientifique-from-europePmc.pdf 2159727 application/pdf CC BY-4.0 0a2bf79f-ee28-4c0b-be6f-2cda1bd320ce Appendix Public ppat.1010632.g001.jpg 65960 image/jpeg 17fa4106-d76a-41e5-97e5-cce8bed84e81 Appendix Public ppat.1010632.g005.jpg 121257 image/jpeg 12d15fc4-0e39-4dfc-ad56-ff8620e5e882 Appendix Public ppat.1010632.s001.tif 515190 image/tiff 95468f5a-7696-43e3-b36b-e5563bc46956 Appendix Public ppat.1010632.g003.jpg 86195 image/jpeg 00ec1dce-944c-4b23-b010-0ee9bc676ddd Appendix Public ppat.1010632.g002.jpg 144064 image/jpeg 9166b082-7df1-4353-be67-9716294a3b6f Appendix Public ppat.1010632.s002.tif 1592414 image/tiff 1fd03d20-3e18-4d3f-bf35-908f97e063aa Appendix Public ppat.1010632.s007.tif 10904436 image/tiff c2cd5a67-e624-45bb-85af-6cac764b454c Appendix Public ppat.1010632.s005.tif 658316 image/tiff ad24d6f5-cc6e-4104-b98a-cf63be07ecc5 Appendix Public ppat.1010632.s008.tif 857090 image/tiff b755a0a3-ed40-4777-a76b-023e8b3db0c5 Appendix Public ppat.1010632.s004.tif 1813414 image/tiff 3ead763a-1fb9-4daf-8a5a-0b48bee3a8d5 Appendix Public ppat.1010632.s006.tif 21823740 image/tiff 5a6c5b16-1ebf-4572-8029-d12fbc7344b8 Appendix Public ppat.1010632.s003.tif 1725186 image/tiff 5b99bfe4-8d95-4666-a67d-04e882cc576e Appendix Public ppat.1010632.g004.jpg 91159 image/jpeg 61ca0de0-abf7-4dcd-8a56-5e7271af4917 Appendix Public ppat.1010632.s009.tif 603356 image/tiff openAccess Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire

Title	Published in	Year	Views	Downloads

Comparison of tissue tropism and host response to enteric and respiratory enteroviruses	PLOS pathogens	2022	583	286
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Cordeiro Filipe, Inès