Temporal plasticity of apical progenitors in the developing mouse neocortex

Article Article scientifique Article Temporal plasticity of apical progenitors in the developing mouse neocortex eng 2019 author Oberst Polina 846753 author Fievre Sabine 850352 author Baumann Natalia 752648 author Concetti Cristina 883048 author Bartolini Giorgia 844731 author Jabaudon Denis 0000-0003-2438-4769 682473 370-374 10.1038/s41586-019-1515-6 31462778 0028-0836 https://www.nature.com/articles/s41586-019-1515-6 The diverse subtypes of excitatory neurons that populate the neocortex are born from apical progenitors located in the ventricular zone. During corticogenesis, apical progenitors sequentially generate deep-layer neurons followed by superficial-layer neurons directly or via the generation of intermediate progenitors. Whether neurogenic fate progression necessarily implies fate restriction in single progenitor types is unknown. Here we specifically isolated apical progenitors and intermediate progenitors, and fate-mapped their respective neuronal progeny following heterochronic transplantation into younger embryos. We find that apical progenitors are temporally plastic and can re-enter past molecular, electrophysiological and neurogenic states when exposed to an earlier-stage environment by sensing dynamic changes in extracellular Wnt. By contrast, intermediate progenitors are committed progenitors that lack such retrograde fate plasticity. These findings identify a diversity in the temporal plasticity of neocortical progenitors, revealing that some subtypes of cells can be untethered from their normal temporal progression to re-enter past developmental states. Dewey 616.8 53 Département de neurosciences fondamentales 21A 61 Département des neurosciences cliniques 226 false 540 Neurobiologie développementale et plasticité 880 https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE122644 Nature 573 7774 0e9d7d97-b321-409c-ac20-e377eaf69c52 Article (Published version) Restricted s41586-019-1515-6.pdf 11873125 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

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Temporal plasticity of apical progenitors in the developing mouse neocortex	Nature			2019	665	5

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Concetti, Cristina