The Interplay between Glucose-Regulated Protein 78 (GRP78) and Steroids in the Reproductive System

Article Article scientifique Article The Interplay between Glucose-Regulated Protein 78 (GRP78) and Steroids in the Reproductive System eng 2018 author Hebert-Schuster Marylise author Rotta Belinda Elisabeth 877721 author Kirkpatrick Brenna 880137 author Guibourdenche Jean author Cohen Marie-Benoîte 0000-0003-4621-5464 135615 1842 10.3390/ijms19071842 29932125 1661-6596 http://www.mdpi.com/1422-0067/19/7/1842 The glucose-regulated protein 78 (GRP78) is a molecular chaperone that is responsible for protein folding, which belongs to the heat shock protein 70 kDa (HSPA/HSP70). Because of the conjunction of GRP78 transcription with endoplasmic reticulum stress, the chaperone plays an important role in the unfolded protein response (UPR), which is induced after the accumulation of misfolded proteins. In the last years, a significant body of research concentrated on interplay between GRP78 and sexual steroid hormones. Throughout this review, we describe the mechanisms by which GRP78 regulates steroidogenesis at multiple levels and how steroids modulate GRP78 expression in different mammalian reproductive organs. Finally, we discuss the cooperation between GRP78 and steroids for cell survival and proliferation in the context of reproduction and tumorigenesis. This new paradigm offers significant opportunities for future exploration. Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 584 Laboratoire de biologie des tumeurs gynécologiques et du développement 927 International Journal of Molecular Sciences 19 7 eb37a81a-7221-47d2-b853-7e3afb5c04b8 Article (Published version) Public ijms-19-01842.pdf 788371 application/pdf CC BY openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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The Interplay between Glucose-Regulated Protein 78 (GRP78) and Steroids in the Reproductive System	International Journal of Molecular Sciences			2018	516	319

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Kirkpatrick, Brenna