Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes

Article Article scientifique Article Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes eng 2024-09-15 2024-12 author Follonier Cédric Vincent 0000-0001-6848-4978 Faculty of Medicine, University of Geneva, Switzerland.,Division of Cardiology, Geneva University Hospitals, Switzerland. 839196 author Rabassa Gabriel Flavien Faculty of Medicine, University of Geneva, Switzerland. 879458 author Branca Mattia 0000-0002-8063-7882 Department of Clinical Research, University of Bern, Switzerland. author Carballo David Andrés Division of Cardiology, Geneva University Hospitals, Switzerland. 30060 Département de médecine (DEMED) author Koskinas Konstantinos Department of Cardiology, University Hospital of Bern, Switzerland. author Heg Dik Department of Clinical Research, University of Bern, Switzerland. author Nanchen David Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland. author Räber Lorenz Department of Cardiology, Bern University Hospital and University of Bern, Bern, Switzerland. author Klingenberg Roland Department of Cardiology, University Heart Center, University of Zurich, Switzerland. author Haller Moa Lina 0009-0006-2380-349X Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland. author Carballo Juan Sebastian 0000-0002-8344-4293 Department of General Internal Medicine, Geneva University Hospitals, Geneva, Switzerland. 84409 Département de médecine (DEMED) author Windecker Stephan Department of Cardiology, University Hospital of Bern, Switzerland. author Matter Christian M Department of Cardiology, University Heart Center, University of Zurich, Switzerland. author Rodondi Nicolas Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.,Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland. author Mach François Division of Cardiology, Geneva University Hospitals, Switzerland. 27365 Département de médecine (DEMED) author Gencer Baris Division of Cardiology, Geneva University Hospitals, Switzerland.,Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.,Service of Cardiology, Lausanne University Hospital, Lausanne, Switzerland. 666056 Département de médecine (DEMED) 1-8 10.1016/j.athplu.2024.09.002 39351317 2667-0895 PMC11439545 https://www.sciencedirect.com/science/article/pii/S2667089524000439 Background and aims: The 2019 European Society of Cardiology guidelines for the management of dyslipidemia consider the use of high-dose marine omega-3 fatty acid (FA) eicosapentaenoic acid (EPA) supplementation (icosapent ethyl 2 × 2g/day) to lower residual cardiovascular risk in high-risk patients with hypertriglyceridemia. This study aimed to assess the eligibility for omega-3 FA-EPA supplementation in patients with acute coronary syndromes (ACS). Methods: In a prospective Swiss cohort of patients hospitalized for ACS, eligibility for marine omega-3 FA-EPA, defined as plasma triglyceride levels ranging from 1.5 to 5.6 mmol/l, was assessed at baseline and one-year follow-up and compared across subgroups. Lipid-lowering therapy intensification with statin and ezetimibe was modelled to simulate a hypothetical systematic treatment and its effect on omega-3 FA-EPA supplementation eligibility. Results: Of 2643 patients, 98 % were prescribed statin therapy at discharge, including 62 % at a high-intensity regimen; 93 % maintained it after one year, including 53 % at a high-intensity regimen. The use of ezetimibe was 3 % at discharge and 7 % at one year. Eligibility was observed in 32 % (32 % men, 29 % women) one year post-ACS. After modelling systematic treatment with statins, ezetimibe, and both, eligibility decreased to 31 %, 25 % and 24 %, respectively. Eligibility was higher in individuals aged <70 (34 vs 25 %), smokers (38 vs 28 %), diabetics (46 vs 29 %), hypertensive (35 vs 29 %), and obese patients (46 vs 22 % for normal weight), all with p-values <0.001. Conclusion: In a contemporary Swiss cohort of patients with ACS, up to 32 % would be eligible for omega-3 FA-EPA supplementation one year after ACS, highlighting an opportunity to mitigate residual cardiovascular risk in patients with ACS and hypertriglyceridemia. Acute coronary syndrome Dyslipidemia Heart disease risk factor Hypertriglyceridemia Omega-3 fatty acids Secondary prevention Dewey 616 Swiss National Science Foundation Inflammation and acute coronary syndrome (ACS) - novel strategies for prevention and clinical management 124112 CH Swiss National Science Foundation Inflammation and acute coronary syndrome (ACS) - novel strategies for prevention and clinical management 140336 CH Swiss National Science Foundation Long-term Benefit of the Multi-Center, Multi-Dimensional Secondary Prevention Program in Patients With Acute Coronary Syndromes 163271 CH Swiss National Science Foundation Moderate alcohol consumption and heart function in patients with a recent myocardial infarction: a multicentre randomized controlled trial 207881 CH Swiss National Science Foundation Preventive care in type 2 diabetes: improving risk prediction among older and multimorbid adults and assessing the effects of novel anti-diabetic drugs 204361 CH 56 Département de médecine 221 false 325 Athérosclérose 591 Atherosclerosis plus 58 8cf1f315-fe05-4ee3-8b38-485a8426719a Article (Published version) Public Article_scientifique_from_europePmc.pdf 1068381 application/pdf CC BY-4.0 cd289be0eccf00ac3d4bd9a8687dc4f85af0a192b4b99489e73ff08c2d71c2f6 a15c3609-d58a-48ae-a0ab-9a8fb9880f17 Appendix Public mmc1.docx 112850 application/vnd.openxmlformats-officedocument.wordprocessingml.document 07d2895f65f8f110e25f09b56ceb348565f4ccc25ace500e81d2e3c150ae1152 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes	Atherosclerosis plus			2024	14	25

Archive ouverte UNIGE

Rabassa, Gabriel Flavien