Vaccine immunity in patients with 22q11.2 microdeletion syndrome

Article Article scientifique Article Vaccine immunity in patients with 22q11.2 microdeletion syndrome eng 2025-02-10 2025-02 author Farpour Leïla Luz Cerise Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland. 878234 author Gualtieri Renato 0000-0001-8164-7284 Platform for Pediatric Clinical Research, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. 974851 author Kotalova Tereza Pole Autism Foundation, Geneva, Switzerland. 971652 Section de psychologie (PSICO) author Lemaitre Barbara Vaccinology Laboratory, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. 649671 author Ducreux Julie Flow Cytometry Lab, Diagnostic Department, Service of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland. 892297 author Arm-Vernez Isabelle Virology Laboratory, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. 690605 author Eliez Stéphan 0000-0002-8269-3028 Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 39336 Département de psychiatrie (PSYAT) author Blanchard Rohner Géraldine 0000-0002-9974-2172 Unit of Immunology, Vaccinology, and Rheumatology, Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. 518713 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) e70043 10.1111/pai.70043 39927887 0905-6157 https://onlinelibrary.wiley.com/doi/10.1111/pai.70043 Background: Patients with microdeletion 22q11.2 syndrome (MDS) exhibit immunological defects, characterized by abnormalities in the development of the thymus, which plays a crucial role in T-cell maturation and immune response. As a result, these patients may have impaired adaptive immunity, with decreased responses to vaccination. Methods: This was a prospective observational study. Vaccine serology (tetanus, diphtheria, Haemophilus influenzae type b for children <5 years, measles, varicella, hepatitis A and B, and SARS-CoV-2) and immune parameters were assessed in MDS patients aged between 1 and 25 years followed in Geneva between February 2022 and April 2023. Results: 41 MDS patients were included. The median age was 13 years old. Most of them reported recurrent otitis and bronchitis up to 10 years, and a mild COVID-19 disease in the past. Immunological work-up indicated normal immunoglobulin levels and lymphocyte counts for the majority. Most patients were well vaccinated for tetanus, diphtheria, Haemophilus influenzae type b and measles, but only half were fully vaccinated for hepatitis B, and SARS-CoV-2 and only a quarter for hepatitis A. 70% of the patients had received 3 doses of pneumococcal conjugate vaccine in infancy but only a minority an additional dose. While most of them were seroprotected against tetanus, diphtheria, and Hib, a substantial number lacked seroprotection against varicella, measles, hepatitis B, and pneumococcus. Conclusion: This study suggests that regular assessment of antibody levels for measles, hepatitis B, varicella, and pneumococcus, regardless of vaccination status should be encouraged in MDS patients, with reimmunization according to vaccine serology, to enhance vaccine immunity. 22q11.2 microdeletion syndrome 31 vaccination Immunology workup Vaccine immunity Humans Female Male Child Child, Preschool Adolescent Prospective Studies DiGeorge Syndrome / immunology Infant Vaccination Young Adult SARS-CoV-2 / immunology COVID-19 / immunology Adult Vaccines / immunology Dewey 616.89 Dewey 616 Dewey 616.07 Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 60 Département de psychiatrie 225 56 Département de médecine 221 137 Département de pathologie et immunologie 21F false 421 Laboratoire d'imagerie et de psychopathologie développementale 693 Pediatric allergy and immunology 36 2 8c70a6ca-959a-4317-90e8-ec2f7eb07736 Article (Published version) Restricted Pediatric_Allergy_Immunology_-_2025.pdf 2050957 application/pdf fc4bb3a8cc6859ea0d990ae3730629f9850ff73a9e5b447accba8eb6dbd3a8e9 7d69f743-b686-4cfb-b79f-80c4b81aad44 Article (Accepted version) Public Manuscrit_220125_clean_and_Figures_.pdf 641197 application/pdf Restricted 2026-03-01 bb9b23f3e63678b9040724f1ca4c68f57a3f852167d2f861f2a772a9138a3c1d 2d28086c-624f-43f1-8245-494ba21096ff Appendix Public Supplementary_figures_220125.docx 30611 application/vnd.openxmlformats-officedocument.wordprocessingml.document Suppl. figures 0351e00b866b274f1cf98075e08957baee5b63f87867030feb92b3a4a8757d76 8b983845-ab58-46d9-a298-c52f584bd1fb Appendix Public Supplementary_tables_220125.docx 32874 application/vnd.openxmlformats-officedocument.wordprocessingml.document Suppl. tables 118b04fc5a2f7357ca473f509a16e9e09d6cb52829b175e42ef97bea98030f42 openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

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Reply to Hinpetch Daungsupawong	Pediatric allergy and immunology	2025	31	0
Vaccine immunity in patients with 22q11.2 microdeletion syndrome	Pediatric allergy and immunology	2025	95	306

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Farpour, Leïla Luz Cerise