Toxicological thresholds of food allergens

Diplôme Master d'études avancées Toxicological thresholds of food allergens eng 2021-08-25 author Rakotomanga Hantarivony Hasina 868252 director Scherl Alexander 500181 Food allergy is a condition in which exposure to certain food may trigger adverse reaction, mediated by an immunologic mechanism that involves specific immunoglobulin E (IgE-mediated) or cell-mediated mechanisms (non-IgE-mediated). It is a growing public health concern affecting children and adults, with reported increased prevalence for some allergens. The severity of allergic reactions can range from mild to potentially life-threatening. Both milk and peanut are among food allergens recognized as such in view of their high prevalence and the severity of the reactions they can cause in certain subjects who are allergic to them. A review was conducted in order to address the state of evidence base in the fields of IgE-mediated allergy to cow's milk and to peanut. Studies reported that 50% of the population allergic to cow's milk proteins and to peanut proteins are likely to experience adverse reactions with 36 mg and 24 mg proteins (median ED50), respectively. Worldwide, food regulations have been implemented considering food allergens with the highest reported prevalence. Their main provisions concern the labeling of allergens. However, studies have demonstrated that these provisions are currently not sufficient, particularly due to the unintentional presence of traces of allergens in certain foods and the lack of regulatory framework in this regard. Thus, this confirms the relevance of thresholds below which most sensitized consumers are not at risk of developing severe allergic reactions, with the aim of adapting current regulations. Food allergy Prevalence Allergens Methods of detection Eliciting dose Thresholds Food labelling Dewey 610 Dewey 615 Master of Advanced Studies in Toxicology 31 Section des sciences pharmaceutiques 17 3 Faculté de médecine 2 false 13c36991-b47a-4918-bf24-e14af3dc9adc Master thesis Restricted 20210823 Final_MAS_Thesis_Hasina_Ra.pdf 1057819 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques Faculté de médecine

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Rakotomanga, Hantarivony Hasina