How Shaped Light Discriminates Nearly Identical Biochromophores

Article Article scientifique Article How Shaped Light Discriminates Nearly Identical Biochromophores eng 2010 author Petersen Jens Martin 86200 author Mitrić Roland author Bonačić-Koutecký Vlasta author Wolf Jean-Pierre 0000-0003-3729-958X 631266 author Roslund Jonathan author Rabitz Herschel 10.1103/PhysRevLett.105.073003 0031-9007 We present a general mechanism for successful discrimination of spectroscopically indistinguishable biochromophores by shaped light. For this purpose we use nonadiabatic dynamics in excited electronic states in the frame of the field-induced surface hopping method driven by the experimentally shaped laser fields. Our findings show that optimal laser fields drive low-frequency vibrational modes localized in the side chains of two biochromophores, thus selecting the parts of their potential energy surfaces characterized by different transition dipole moments leading to different ionization probabilities. The presented mechanism leads to selective fluorescence depletion which serves as a discrimination signal. Our findings offer a promising perspective for using optimally shaped laser pulses in bioanalytical applications by increasing the selectivity beyond the current capability. Dewey 500.2 35 Groupe de physique appliquée 135 false Physical review letters 105 7 bd304f68-4f9f-4e39-9071-1f91b6dadf71 Article (Published version) Public Wolf41_2010.pdf 787896 application/pdf openAccess Faculté des sciences / Section de physique / Groupe de physique appliquée

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How Shaped Light Discriminates Nearly Identical Biochromophores	Physical review letters			2010	747	954

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Petersen, Jens Martin