BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin

Article Article scientifique Article BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin eng 2020 author Mateus Domingos Rita 946313 author Holtzer Laurentius Henricus 722865 author Seum Carole 22058 author Hadjivasiliou Zena 861363 author Dubois-Barthelemy Marine 675070 author Jülicher Frank author Gonzalez Gaitan Marcos 645929 4292-4302 10.1016/j.celrep.2020.03.024 2211-1247 https://linkinghub.elsevier.com/retrieve/pii/S2211124720303387 Secreted growth factors can act as morphogens that form spatial concentration gradients in developing organs, thereby controlling growth and patterning. For some morphogens, adaptation of the gradients to tissue size allows morphological patterns to remain proportioned as the organs grow. In the zebrafish pectoral fin, we found that BMP signaling forms a two-dimensional gradient. The length of the gradient scales with tissue length and its amplitude increases with fin size according to a power-law. Gradient scaling and amplitude power-laws are signatures of growth control by time derivatives of morphogenetic signaling: cell division correlates with the fold change over time of the cellular signaling levels. We show that Smoc1 regulates BMP gradient scaling and growth in the fin. Smoc1 scales the gradient by means of a feedback loop: Smoc1 is a BMP agonist and BMP signaling represses Smoc1 expression. Our work uncovers a layer of morphogen regulation during vertebrate appendage development. Morphogen Gradient Scaling Organ growth BMP Smoc1 Zebrafish Pectoral fin Theoretical physics Dewey 540 39 Département de biochimie 144 false Cell Reports 30 12 de3d79e8-acae-4cb4-9611-539020dc9007 Article (Published version) Public Bmp_MG_20.pdf 4732409 application/pdf openAccess Faculté des sciences / Section de chimie et biochimie / Département de biochimie

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BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin	Cell Reports			2020	609	277

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Hadjivasiliou, Zena