The role of c-kit (CD117) and its crosstalk with integrins for controlling cell adhesion and spreading: implications for therapeutic resistance of leukaemia

Diplôme Thèse The role of c-kit (CD117) and its crosstalk with integrins for controlling cell adhesion and spreading: implications for therapeutic resistance of leukaemia eng 2020-10-02 author Chebbi-Mathlouthi Seimia 860704 director Wehrle-Haller Bernhard 0000-0002-1159-1147 116298 10.13097/archive-ouverte/unige:153036 urn:nbn:ch:unige-1530360 Sc. Vie - Bioméd. 75 Kit Ligand (KitL) or Stem Cell Factor (SCF) and its receptor tyrosine kinase, c-Kit (CD117) are critical for the survival of germ cells, melanocytes, hematopoietic stem cells and mastocytes. Overexpression and gain-of-function mutations of c-kit were detected in several human cancers such as leukemia. Despite treatments with tyrosine kinase inhibitors (TKIs) notably, imatinib, tumor cells persist in the tissue microenvironment of the bone marrow in an integrin-dependent manner. These resident tumor cells can cause the development of therapy resistance due to secondary mutations in c-Kit and tumor relapse. So far, it is not understood why tumor cells are sensitive to TKI inhibitors when present in the blood, but escape this treatment when anchored to their niche in the bone marrow. C-kit CD117 Integrin Cell spreading Cell adhesion Tyrosine kinase receptor Tyrosine kinase inhibitor Imatinib Dasatinib Leukaemia Crosstalk Dewey 612 Swiss National Science Foundation 166384 CH 134 Département de physiologie cellulaire et métabolisme 21C false 379 Migration cellulaire 645 85110c76-d754-4784-92ac-57dee1cab66b Thesis Restricted ThesisSeimiaChebbi-Mathlouthi2020.pdf 18912331 application/pdf da96ddef1076c5008078c01f29e5da9a1c58006db64e13f82a168f52b9dd6660 restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Title	Published in	Access level	OA Policy	Year	Views	Downloads

The role of c-kit (CD117) and its crosstalk with integrins for controlling cell adhesion and spreading: implications for therapeutic resistance of leukaemia				2020	577	7

Archive ouverte UNIGE

Chebbi-Mathlouthi, Seimia