Rhinovirus infections among hematopoietic stem cell transplant recipients: a pre-transplant dilemma?

Article Article scientifique Article Rhinovirus infections among hematopoietic stem cell transplant recipients: a pre-transplant dilemma? eng 2022-01-28 2022-01-28 author Barral Sébastien 0000-0002-7646-8940 857982 author Mamin Aline 133667 author Dantin Carole Alice 90319 author Masouridi Levrat Stavroula 844685 author Chalandon Yves 0000-0001-9341-8104 644957 author Kaiser Laurent 28229 author Vu Cantero Diem-Lan 527382 267 10.3390/v14020267 35215861 1999-4915 PMC8879386 Respiratory viral infections (RVIs) in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients can be of concern due to the patients' depressed immune status, but few data are available about the significance of a pre-transplant positive testing. In this retrospective observational study, we analyzed a cohort of patients that were transplanted between 1 January 2010 and 31 October 2019 in the Geneva University Hospitals with at least one RVI before or after transplantation. At least one RVI was detected in 319/533 (63.5%) transplanted patients. Rhinoviruses were most frequently identified (37%), followed by human coronaviruses (17.1%), parainfluenza viruses (13.9%), and influenza viruses (9.9%). First infection in the post-transplant period occurred at a mean time of 334 days (SD 338). Specific analysis of a subgroup of 65 patients with pre-transplant RVIs was performed. Among them, 39 (59%) patients had symptoms and 14 (21.2%) had a lower respiratory tract infection. Four patients (6.1%) (three rhinovirus and one influenza) needed an intensive care unit admission, of which, three (4.5%) (two rhinovirus and one influenza) were intubated. The patient with influenza infection diagnosed the day of the transplantation died within the first 30 days of the infection. Two patients with rhinovirus infection died within 3 months of unrelated causes. Our data show that rhinovirus infections are predominant in allo-HSCT patients, including among pre-transplant infections; however, mortality due to pre-transplant RVI is low and was only clearly identified in one patient with influenza infection. RVI within the month preceding allo-HSCT is not associated with direct morbidity or mortality in this cohort. Respiratory virus Rhinovirus Shedding Stem cell transplantation Female Hematopoietic Stem Cell Transplantation Humans Influenza, Human / epidemiology Male Middle Aged Picornaviridae Infections / epidemiology Preoperative Period Respiratory Tract Infections / epidemiology Retrospective Studies Rhinovirus Transplant Recipients Dewey 616 56 Département de médecine 221 false 1216 Leucémie et transplantation allogénique de cellules souches hématopoïétiques 982 400 Virologie clinique 668 Viruses 14 2 0aa4cbbb-f9d3-401e-95ca-cfa59b23ccc3 Article (Published version) Public viruses-14-00267.pdf 422186 application/pdf CC BY 5b96453e-2163-49f8-94e2-121e2f1be8da Supplemental data Public viruses-14-00267-s001(1).zip 79049 application/zip openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Rhinovirus infections among hematopoietic stem cell transplant recipients: a pre-transplant dilemma?	Viruses			2022	214	216

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Barral, Sébastien