Exploring synergistic interactions between downregulated genes and ATR inhibition in cancerous cells

Diplôme Master Exploring synergistic interactions between downregulated genes and ATR inhibition in cancerous cells eng 2022-01-27 author Graulich Elise 857520 director Halazonetis Thanos 641033 director Rossetti Giacomo 861180 Cancer is considered as one of the principal cause of death worldwide1. However, these past years, new technologies and knowledge on cancer cells arose which led to the development of more specific treatments, better adapted to each tumor, resulting in better outcomes for the patients. This approach often relies on the discovery of new synthetic lethal interactions between drug compounds and tumor-specific gene expression. ATR (ataxia telangiectasia and Rad3-related protein) is a kinase involved in many pathways of the DNA damage response and was shown to be overactivated in many different cancers. Inhibitors of this protein have been developed recently and are now used in chemotherapies to treat advanced tumors. In this report, we found that DNA damage caused by the ATR inhibitor BAY1895344 in Hela and U2OS cancerous cell lines could be increased when combined with inhibition of SMARCA4, RAD52, FBXW7, MACROD1 or PKMYT1. Understanding these synergies could further help to improve the efficiency of treatments involving ATR inhibitors. Dewey 570 Master in Genetics, Development and Evolution 43 Département de biologie moléculaire 161 false 811 Groupe Halazonetis 4ed9219c-4e5a-4bd8-b1dc-8fcd6d29018a Master thesis Restricted Master Thesis - Elise Graulich.pdf 12903094 application/pdf CC BY restrictedAccess Faculté des sciences / Section de biologie / Département de biologie moléculaire

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Exploring synergistic interactions between downregulated genes and ATR inhibition in cancerous cells				2022	98	15

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Graulich, Elise

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