Endoscopic resection with adjuvant chemo-radiotherapy for superficial esophageal squamous cell carcinoma: A critical review

Article Article scientifique Revue de la littérature Endoscopic resection with adjuvant chemo-radiotherapy for superficial esophageal squamous cell carcinoma: A critical review eng 2018-03-02 2018-04 author Kam Tsz Yeung 882422 author Kountouri Melpomeni 912076 author Roth Arnaud 134504 author Frossard Jean-Louis 35038 author Huber Olivier 856791 author Moenig Stefan Paul 825376 author Zilli Thomas 791833 61-65 10.1016/j.critrevonc.2018.02.011 29548487 1040-8428 https://www.sciencedirect.com/science/article/pii/S1040842817305097 Radical esophagectomy with extended lymph node dissection is considered the standard of care in treatment of squamous cell carcinoma of esophagus with deep mucosal invasion (pT1a m3) or submucosal involvement (pT1b). However, despite the increasing use of minimally invasive approaches, it remains a major surgery associated with significant morbidities and even mortality risk. Endoscopic resection (ER) results in excellent local control in early superficial mucosal (pT1a) disease yet there is substantial risk of lymph node metastases in T1b disease. Therefore, ER followed by combined with chemo-radiotherapy (CRT) would potentially improve the outcome in pT1a m3 or pT1b disease and would be an attractive conservative alternative to esophagectomy. Retrospective series published so far have shown promising results for this combined treatment. Herein the current literature of the indications, treatment outcome and toxicities of this treatment strategy are discussed and critically reviewed. Chemotherapy Endoscopic dissection Esophageal cancer Radiotherapy Submucosal Carcinoma, Squamous Cell / pathology Carcinoma, Squamous Cell / therapy Chemoradiotherapy Chemotherapy, Adjuvant Combined Modality Therapy / methods Endoscopic Mucosal Resection / methods Esophageal Neoplasms / pathology Esophageal Neoplasms / therapy Esophageal Squamous Cell Carcinoma Esophagectomy / methods Humans Neoplasm Staging Radiotherapy, Adjuvant Retrospective Studies Treatment Outcome Dewey 616 Dewey 616.0757 Dewey 617 56 Département de médecine 221 57 Département de chirurgie 222 62 Département de radiologie et informatique médicale 227 false 1329 Chirurgie viscérale (HUG) 223 Groupe Roth Arnaud (oncologie) 285 1299 Laboratoire de radiothérapie de haute précision pour le cancer de la prostate 1014 335 Pancréatite aiguë 601 562 Transplantation et hépatologie 905 Critical reviews in oncology/hematology 124 ddcd8324-1b5d-4da4-8bbd-d417fce1dbcd Article (Published version) Restricted Kam_Monig_Critical_Review_2018.pdf 168428 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Endoscopic resection with adjuvant chemo-radiotherapy for superficial esophageal squamous cell carcinoma: A critical review	Critical reviews in oncology/hematology			2018	333	0

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Huber, Olivier