Basal forebrain metabolism in Alzheimer's disease continuum: relationship with education

Article Article scientifique Article Basal forebrain metabolism in Alzheimer's disease continuum: relationship with education eng 2020 author Brandt Nicolas Philippe 854804 author Dodich Alessandra 896999 author Perani Daniela author Ratib Osman 28848 author Trombella Sara 787119 author Frisoni Giovanni 810190 author Garibotto Valentina 0000-0003-2422-698X 704817 Alzheimer's Disease Neuroimaging Initiative 70-77 10.1016/j.neurobiolaging.2019.11.013 32008856 0197-4580 We analyzed education, as a proxy of cognitive reserve, and the cholinergic pathway in Alzheimer's disease (AD), to test the hypothesis that education might modulate the relationship between clinical symptoms and metabolic and structural changes in AD. We included 84 subjects and compared between diagnostic groups and different educational levels the glucose metabolism of basal forebrain (BFM) and volume of the basal forebrain, the major cholinergic structure, and hippocampus (HM) (and hippocampal volume), a relevant projection site for the basal forebrain. Correlations with the global cognitive status and education in the whole sample were also performed. Patients with AD dementia showed reduced basal forebrain volume, hippocampal volume, and HM compared with controls. In the whole group, the global cognitive status was positively correlated with BFM and HM. Among high-educated subjects, mild cognitive impairment showed higher BFM and HM in comparison to other diagnostic groups. Our results suggest that in mild cognitive impairment subjects with a higher educational level, cholinergic activity is upregulated and this appears to have a compensatory effect, which may be lost in later symptomatic stages. Aged Aged 80 and over Alzheimer Disease/metabolism/pathology/psychology Cognitive Dysfunction/pathology Cognitive Reserve Educational Status Female Glucose/metabolism Hippocampus/metabolism/pathology Humans Male Organ Size Prosencephalon/metabolism/pathology Dewey 616.0757 Dewey 618.97 Swiss National Science Foundation The Biological Basis of Cognitive Impairment due to Suspected Non-Alzheimer's Pathology (SNAP) : Studying the interplay between amyloidosis and tau-related neurodegeneration 320030_169876 CH Project funding 62 Département de radiologie et informatique médicale 227 65 Département de réadaptation et gériatrie 22B false 1222 Laboratoire de neuroimagerie et de traceurs moléculaires innovants 984 853 Troubles de mémoire et maladie d'Alzeimer 935 Neurobiology of Aging 87 5254dc06-6d8b-478a-a440-e7b2e01371b0 Article (Published version) Restricted 1-s2.0-S0197458019304191-main.pdf 1025924 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

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Basal forebrain metabolism in Alzheimer's disease continuum: relationship with education	Neurobiology of Aging			2020	449	0

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Brandt, Nicolas Philippe