Attention and emotion in adolescents with ADHD; a time-varying functional connectivity study

Article Article scientifique Article Attention and emotion in adolescents with ADHD; a time-varying functional connectivity study eng 2024-11-15 2025-03-01 author Rafi Halima Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; Developmental Neuroimaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland. Electronic address: halima.rafi@unige.ch. 846580 author Samson Jessica Lee Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; Developmental Neuroimaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland. 850731 author Barrios Rudloff Juan 0000-0003-0709-8306 Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; Developmental Neuroimaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland. 846621 Département de médecine (DEMED) author Poznyak Elena Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; Developmental Neuroimaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland. 774923 author Gauthey Mélissa Patricia Hélène Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; Developmental Neuroimaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland. 854626 author Perroud Nader Ali 0000-0002-9282-9216 Service of psychiatric specialties, Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland. 94458 Département de psychiatrie (PSYAT) author Debbané Martin Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; Developmental Neuroimaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland; Research Department of Clinical, Educational & Health Psychology, University College London, London, United Kingdom. 543333 Section de psychologie (PSICO) 86-95 10.1016/j.jad.2024.11.036 39551190 0165-0327 https://www.sciencedirect.com/science/article/pii/S016503272401869X Background: This study assessed adolescent brain-behavior relationships between large-scale dynamic functional network connectivity (FNC) and an integrated attention-deficit/hyperactivity disorder (ADHD) phenotype, including measures of inattention, impulsivity/hyperactivity and emotional dysregulation. Despite emotion dysregulation being a core clinical feature of ADHD, studies rarely assess its impact on large-scale FNC. Methods: We conducted resting-state functional magnetic resonance imaging in 78 adolescents (34 with ADHD) and obtained experimental and self-reported measures of inattention, impulsivity/hyperactivity, and emotional reactivity. We used multivariate analyses to evaluate group differences in dynamic FNC between the default mode, salience and central executive networks, meta-state functional connectivity and ADHD symptomology. Results: We present two significant group*behavior effects. Compared to controls, adolescents with ADHD had 1) diminished salience network-centered dynamic FNC that was driven by an integrated ADHD phenotype (p < .004, r = 0.57) and 2) more variable patterns of global connectivity, as measured through meta-state analysis, which were driven by heightened emotional reactivity (p < .002, r = 0.63). Conclusions: Atypical patterns of dynamic FNC in adolescents with ADHD are associated with the affective and cognitive components of ADHD symptomology. Limitations include sample size and self-reported measures of emotional reactivity. ADHD Adolescent development Dynamic functional connectivity Emotion regulation Emotional reactivity Meta-state analysis FMRI Dewey 616.89 Dewey 150 Swiss National Science Foundation Examining the contribution of mentalization in adolescent attentional difficulties 179033 CH Projects 60 Département de psychiatrie 225 108 Section de psychologie 71 false 1342 Régulation des émotions : TDAH et trouble de la personnalité borderline 1028 603 Unité de psychologie clinique développementale (UPCD) Journal of affective disorders 372 0fff0e23-d34b-4148-88a3-fbdcc866d37d Article (Published version) Public 1-s2.0-S016503272401869X-main_rafi.pdf 3433403 application/pdf CC BY-4.0 3b4e7ea7106ca192da4d2787d395e48d36b22fd10924f8cfa7c5d234cf1a49f0 5aa55e3a-9427-4b5a-a39e-fc17cf48dfdf Supplemental data Public 1-s2.0-S016503272401869X-mmc1.docx 927573 application/vnd.openxmlformats-officedocument.wordprocessingml.document 75e9c453bc14f73e3b44a40e545e671fc7dcec9fde68bf122d97ae3f566725da openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de psychologie et des sciences de l'éducation / Section de psychologie

Title	Published in	Year	Views	Downloads

Attention and emotion in adolescents with ADHD; a time-varying functional connectivity study	Journal of affective disorders	2025	29	32
Traitement sensoriel, mentalisation et symptômes d'inattention-hyperactivité de l'adolescence à l'âge adulte : une perspective clinique et développementale		2022	73	13

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