Developmental trajectories of cortical thickness in relation to schizotypy during adolescence

Article Article scientifique Article Developmental trajectories of cortical thickness in relation to schizotypy during adolescence eng 2020 author Derome Melodie 846041 author Tonini Emiliana 852511 author Zoeller Daniela 846743 author Schaer Marie 0000-0001-8479-6365 510515 author Eliez Stéphan 39336 author Debbané Martin 543333 10.1093/schbul/sbaa020 32133513 0586-7614 Investigating potential gray matter differences in adolescents presenting higher levels of schizotypy personality traits could bring further insights into the development of schizophrenia spectrum disorders. Research has yet to examine the morphological correlates of schizotypy features during adolescence prospectively, and no information is available on the developmental trajectories from adolescence to adulthood. We employed mixed model regression analysis to investigate developmental trajectories of cortical thickness (CT) in relation to schizotypy dimensions in a cohort of 109 adolescents from the general population for whom MRI-scans were acquired over a 5-year period, culminating in a total of 271 scans. Structural data were processed with FreeSurfer software, statistical analyses were conducted using mixed regression models following a ROI-based approach, and schizotypy was assessed with the Schizotypal Personality Questionnaire (SPQ). Accelerated thinning was observed in the posterior cingulate cortex in relation to high levels of positive schizotypy, whereas high levels of disorganized schizotypy were associated with a similar trajectory pattern in the anterior cingulate cortex. The developmental course of CT in the prefrontal, occipital, and cingulate cortices differed between adolescents expressing higher vs lower levels of negative schizotypy. Participants reporting high scores on all schizotypy dimensions were associated with differential trajectories of CT in posterior cingulate cortex and occipital cortex. Consistently with prospective developmental studies of clinical risk conversion, the negative schizotypy dimension appears to constitute the most informative dimension for psychosis-related psychopathology, as its cerebral correlates in adolescents most closely overlap with results found in clinical high risk for psychosis studies. Schizophrenia Structural MRI Longitudinal analysis Dewey 150 Dewey 576.5 Dewey 616.0757 Dewey 616.89 Swiss National Science Foundation From schizotypy to clinical high-risk for psychosis: an integrative longitudinal study 159440 CH Project funding Autre Gertrude Von Meissner Foundation (ME 7871 to M.D. and S.E.) 135 Département de médecine génétique et développement 21D 60 Département de psychiatrie 225 62 Département de radiologie et informatique médicale 227 108 Section de psychologie 71 false 421 Laboratoire d'imagerie et de psychopathologie développementale 693 603 Unité de psychologie clinique développementale (UPCD) Schizophrenia Bulletin 3a58bbb9-11d1-4f0d-a2b4-553838b0d10e Article (Published version) Private Development_trajectories_tickness.pdf 617298 application/pdf 41d398ba-a163-4a77-96c0-c9f003f6a3a1 Article (Accepted version) Public Schizophrenia-bulletin_Derome.pdf 3629105 application/pdf Restricted 2021-02-22 f334852b-4e6e-4abf-bb44-287483c5a01e Supplemental data Public sbaa020_suppl_supplementary_material.docx 554675 application/vnd.openxmlformats-officedocument.wordprocessingml.document Restricted 2021-02-22 openAccess Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de psychologie et des sciences de l'éducation / Section de psychologie

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Developmental trajectories of cortical thickness in relation to schizotypy during adolescence	Schizophrenia Bulletin			2020	418	211

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Tonini, Emiliana