Assessing vaccine-induced immunity against pneumococcus, hepatitis A and B over a 9-year follow-up in pediatric liver transplant recipients : A nationwide retrospective study

Article Article scientifique Article Assessing vaccine-induced immunity against pneumococcus, hepatitis A and B over a 9-year follow-up in pediatric liver transplant recipients : A nationwide retrospective study eng 2023-12-14 2024-06 author Gold Temisan Benson Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland. 849342 author Gualtieri Renato 0000-0001-8164-7284 Pediatric Platform for Clinical Research, Department of Pediatrics, Gynecology, and Obstetrics, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland. 974851 author Posfay Barbe Klara Unit of Infectious Diseases, Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. 39230 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Wildhaber Barbara Division of Child and Adolescent Surgery, Department of Pediatrics, Gynecology, and Obstetrics, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland. 595596 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Mclin Valérie Anne Gastroenterology, Hepatology and Nutrition Unit, Division of Pediatric Specialties, Department of Pediatrics, Gynecology, and Obstetrics, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland; Swiss Pediatric Liver Center, Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. 799651 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Blanchard Rohner Géraldine Unit of Immunology and Vaccinology, Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. Electronic address: geraldine.blanchardrohner@hcuge.ch. 518713 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) 1070-1079 10.1016/j.ajt.2023.12.011 38103788 1600-6135 https://www.sciencedirect.com/science/article/pii/S1600613523009115 Pediatric liver transplant recipients are particularly at risk of infections. The most cost-effective way to prevent infectious complications is through vaccination, which can potentially prevent infections due to hepatitis B (HBV) virus, hepatitis A virus (HAV), and invasive pneumococcal diseases. Here, we performed a retrospective analysis of HBV, HAV, and pneumococcal immunity in pediatric liver transplant recipients between January 1, 2009, and December 31, 2020, to collect data on immunization and vaccine serology. A total of 94% (58/62) patients had available vaccination records. At transplant, 90% (45/50) were seroprotected against HBV, 63% (19/30) against HAV, and 78% (18/23) had pneumococcal immunity, but immunity against these 3 pathogens remained suboptimal during the 9-year follow-up. A booster vaccine was administered to only 20% to 40% of patients. Children who had received >4 doses of HBV vaccine and > 2 doses of HAV vaccine pretransplant displayed a higher overall seroprotection over time post-solid organ transplant. Our findings suggest that a serology-based approach should be accompanied by a more systematic follow-up of vaccination, with special attention paid to patients with an incomplete vaccination status at time of transplant. Hepatitis A Hepatitis B Infection Invasive pneumococcal disease Liver transplant Pediatric Vaccination Humans Retrospective Studies Liver Transplantation Male Female Follow-Up Studies Child Hepatitis B / prevention & control Hepatitis B / immunology Child, Preschool Hepatitis A / immunology Hepatitis A / prevention & control Hepatitis B Vaccines / immunology Hepatitis B Vaccines / administration & dosage Hepatitis B virus / immunology Pneumococcal Infections / prevention & control Pneumococcal Infections / immunology Hepatitis A Vaccines / immunology Hepatitis A Vaccines / administration & dosage Adolescent Infant Streptococcus pneumoniae / immunology Prognosis Transplant Recipients Hepatitis A virus / immunology Postoperative Complications / immunology Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 143 Centre de vaccinologie et d'immunologie néonatale 177 515 Recherche en infectiologie pédiatrique et en pédiatrie générale 853 1337 Laboratoire d'immunologie vaccinale humaine 1025 559 Pathologies hépatiques congénitales et acquises de l'enfant 900 546 Recherche clinique en chirurgie pédiatrique 886 American journal of transplantation 24 6 620fefed-80f5-4396-bc42-331db72da251 Article (Published version) Public AJT.pdf 1492372 application/pdf 69c2e070da980349091a91fdb1102dce1381f7d19ab007a4cbaf248fa14b5671 21e1c38c-db42-4553-8198-f3581c17743a Supplemental data Public 1-s2.0-S1600613523009115-mmc1.docx 24155 application/vnd.openxmlformats-officedocument.wordprocessingml.document 2305641cc77945b2dff4862b75d05549950179090e19d369d5579f11dcde00e1 openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Assessing vaccine-induced immunity against pneumococcus, hepatitis A and B over a 9-year follow-up in pediatric liver transplant recipients : A nationwide retrospective study	American journal of transplantation			2024	108	129

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Gold, Temisan Benson