Regional cerebral perfusion and cerebrovascular reactivity in elderly controls with subtle cognitive deficits

Article Article scientifique Article Regional cerebral perfusion and cerebrovascular reactivity in elderly controls with subtle cognitive deficits eng 2019 author Van Der Thiel Merel Margaretha 846297 author Rodriguez Cristelle 511272 author Van De Ville Dimitri 0000-0002-2879-3861 638484 author Giannakopoulos Panteleimon 44657 author Haller Sven 711086 19 10.3389/fnagi.2019.00019 30837863 1663-4365 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390712/ Background: Recent studies suggested that arterial spin labeling (ASL)-based measures of cerebral blood flow (CBF) as well as cerebral vasoreactivity to CO2 (CVR CO2) show significant alterations mainly in posterior neocortical areas both in mild cognitive impairment (MCI) and Alzheimer disease. It remains, however, unknown whether similar changes occur in at risk healthy elders without clinically overt symptoms. This longitudinal study investigated patterns of ASL perfusion and CVR CO2 as a function of the cognitive trajectories in asymptomatic elderly individuals. Methods: Seventy-nine community-dwelling subjects (mean age: 78.7 years, 34 male) underwent three neuropsychological assessments during a subsequent 3-year period. Individuals were classified as stable-stable (SS), variable (V), or progressive-progressive (PP). Between-group comparisons were conducted for ASL CBF and transit-time delay maps and β-maps of CO2 response. Spearman's rho maps assessed the correlation between ASL (respectively, CVR CO2 measures) and Shapes test for working memory, as well as Verbal fluency test for executive functions. Three group-with-continuous-covariate-interaction designs were implemented to investigate group-based differences on the association between neuropsychological scores and ASL or CO2 measures. Results: Comparison of CBF maps demonstrates significantly lower perfusion in the V-group as to PP-cases predominantly in parietal regions, including the precuneus and, to a lesser degree, in temporal and frontal cortex. A stronger CVR CO2 response was found in the PP-group in left parietal areas compared to the V-group. V-cases showed a stronger ASL-Shape value relationship than V-group in right temporoparietal junction and superior parietal lobule. CO2-Shape value correlation was significantly higher in both SS and PP-groups compared to the V-group in right insular and superior perisylvian regions. Conclusion: Our data indicate the presence of decreased ASL and CVR CO2 values mainly in parietal and fronto-temporal areas in cases with the first signs of cognitive instability (V-group). Importantly, the PP-group, at high risk for MCI transition, displays an increase of both parameters in the same areas. Clinicoradiologic correlations also indicate a clear distinction between the V-group and both PP and SS-cases. These data imply the presence of an inverted U-shape pattern of regional blood flow and CVR in old age that might predict subsequent cognitive fate. CO2 Arterial spin labeling Asymptomatic controls Brain perfusion Cerebrovascular reactivity Clinicoradiologic correlations Dewey 616.0757 Swiss National Science Foundation 3200B0-1161193 CH Swiss National Science Foundation The conversion of mild cognitive impairement to alzheimer's disease CH Programmes 62 Département de radiologie et informatique médicale 227 false 161 Groupe Giannakopoulos Panteleimon (psychiatrie générale) 201 926 Imagerie per-opératoire multi-modalité en radiologie interventionnelle 949 552 Traitement d'images médicales 893 Frontiers in Aging Neuroscience 11 e8581d55-6e89-4be2-be47-13d97fe5c748 Article (Published version) Public fnagi-11-00019.pdf 3072096 application/pdf CC BY openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Title	Published in	Year	Views	Downloads

Regional cerebral perfusion and cerebrovascular reactivity in elderly controls with subtle cognitive deficits	Frontiers in Aging Neuroscience	2019	360	172
The relation between the vascular reserve and baseline perfusion in cognitive decline		2017	68	1

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Van Der Thiel, Merel Margaretha