Norine: Update of the Nonribosomal Peptide Resource

Article Article scientifique Article Norine: Update of the Nonribosomal Peptide Resource eng 2020 author Flissi Areski author Ricart Altimiras Emma 844684 author Campart Clémentine author Chevalier Mickael author Dufresne Yoann 876603 author Michalik Juraj author Jacques Philippe author Flahaut Christophe author Lisacek Frédérique 0000-0002-0948-4537 639315 author Leclère Valérie author Pupin Maude D465-D469 10.1093/nar/gkz1000 1362-4962 http://fdslive.oup.com/www.oup.com/pdf/production_in_progress.pdf Norine, the unique resource dedicated to nonribosomal peptides (NRPs), is now updated with a new pipeline to automate massive sourcing and enhance annotation. External databases are mined to extract NRPs that are not yet in Norine. To maintain a high data quality, successive filters are applied to automatically validate the NRP annotations and only validated data is inserted in the database. External databases were also used to complete annotations of NRPs already in Norine. Besides, annotation consistency inside Norine and between Norine and external sources have reported annotation errors. Some can be corrected automatically, while others need manual curation. This new approach led to the insertion of 539 new NRPs and the addition or correction of annotations of nearly all Norine entries. Two new tools to analyse the chemical structures of NRPs (rBAN) and to infer a molecular formula from the mass-to-charge ratio of an NRP (Kendrick Formula Predictor) were also integrated. Norine is freely accessible from the following URL: https://bioinfo.cristal.univ-lille.fr/norine/. Dewey 025.063 Dewey 570 13 Centre universitaire d'informatique 0D3 30 Section de biologie 16 32 Département d'informatique 18 false 1316 Proteome informatics Group Nucleic Acids Research 8 48 76b0e957-63de-4e67-8d4b-36af7277b3ed Article (Published version) Public 2020Flissi_norine_update.pdf 681899 application/pdf CC BY-NC openAccess Centres et instituts / Centre universitaire d'informatique Faculté des sciences / Section de biologie Faculté des sciences / Département d'informatique

Title	Published in	Year	Views	Downloads

Development of Software Platforms for Annotation and Dereplication of Peptidic Natural Products		2020	592	620
Norine: Update of the Nonribosomal Peptide Resource	Nucleic Acids Research	2020	329	466

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Ricart Altimiras, Emma