PLEKHA7: Cytoskeletal adaptor protein at center stage in junctional organization and signaling

Article Article scientifique Revue de la littérature PLEKHA7: Cytoskeletal adaptor protein at center stage in junctional organization and signaling eng 2016-06 author Shah Jimit 747962 author Guerrera Diego 793899 author Vasileva Ekaterina 830288 author Sluysmans Sophie 846301 author Bertels Eva Maria 843562 author Citi Sandra 0000-0002-6537-4818 116085 Département de biologie moléculaire et cellulaire (MOCEL) 112-116 10.1016/j.biocel.2016.04.001 27072621 1357-2725 https://linkinghub.elsevier.com/retrieve/pii/S1357272516300796 <p>PLEKHA7 is a recently characterized component of the cytoplasmic region of epithelial <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/adherens-junction" rel="noopener noreferrer" target="_blank">adherens junctions</a> (AJ). It comprises two WW domains, a pleckstrin-homology domain, and proline-rich and coiled-coil domains. PLEKHA7 interacts with cytoplasmic components of the AJ (p120-catenin, paracingulin, afadin), stabilizes the E-cadherin complex by linking it to the minus ends of noncentrosomal microtubules, and stabilizes junctional <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/nectin" rel="noopener noreferrer" target="_blank">nectins</a> through the newly identified interactor PDZD11. Similarly to afadin, and unlike E-cadherin and p120-catenin, the localization of PLEKHA7 at AJ is strictly zonular (in the <i>zonula adhaerens</i> subdomain of AJ), and does not extend along the basolateral contacts. Genome-wide association studies and experiments on animal and cellular models show that although PLEKHA7 is not required for organism viability, it is implicated in cardiovascular physiology, hypertension, primary angle closure glaucoma, susceptibility to staphylococcal a-toxin, and epithelial <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/morphogenesis" rel="noopener noreferrer" target="_blank">morphogenesis</a> and growth. Thus, PLEKHA7 is a cytoskeletal adaptor protein important for AJ organization, and at the center of junction-associated <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/signal-transduction" rel="noopener noreferrer" target="_blank">signaling pathways</a> which fine-tune important pathophysiological processes.</p> Adherens junctions Afadin Microtubules PDZD11 PLEKHA7 Paracingulin p120catenin Dewey 570 46 Département de biologie cellulaire 165 false 1441 Groupe Citi International journal of biochemistry & cell biology 75 574ba7d4-561b-4405-8ce6-c4881ff68b15 Article (Published version) Restricted CITI02.pdf 746057 application/pdf 1b4bea049d16b211ddba300684b14439714e63572c0600dfd1f4650a957ca23e restrictedAccess Faculté des sciences / Section de biologie / Département de biologie cellulaire

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PLEKHA7: Cytoskeletal adaptor protein at center stage in junctional organization and signaling	International journal of biochemistry & cell biology			2016	64	0

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Bertels, Eva Maria