Plasma biomarkers for Alzheimer's disease: a field-test in a memory clinic

Article Article scientifique Article Plasma biomarkers for Alzheimer's disease: a field-test in a memory clinic eng 2023-04-03 2023-06 author Altomare Daniele 0000-0003-1905-8993 Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland Daniele.Altomare@unibs.it.,Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland.,Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. 917820 author Stampacchia Sara 0000-0001-9545-3376 Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.,Laboratory of Cognitive Neuroscience (LNCO), Center of Neuroprosthetics (CNP) and Brain Mind Institute (BMI), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. 935037 author Ribaldi Federica Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.,Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland. 920118 dept de réadaptation et gériatrie (MIGRG) author Tomczyk Szymon Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.,Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland. 743605 author Chevalier Claire Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.,Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland. 818558 author Poulain Géraldine Sérotheque Centrale / Biotheque SML, Diagnostic Department, Geneva University Hospitals, Geneva, Switzerland. 868190 author Asadi Saina Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland. 923476 author Bancila Bianca Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland. 839267 author Marizzoni Moira Laboratory of Biological Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.,Laboratory of Neuroimaging and Alzheimer's Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. author Martins Marta Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland. 820284 author Lathuilière Aurélien 0000-0002-5191-5214 Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.,Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland. 557604 dept de réadaptation et gériatrie (MIGRG) Aurélien Lathuiliere author Scheffler Max 0000-0003-2274-5129 Division of Radiology, Geneva University Hospitals, Geneva, Switzerland. 686304 Département de radiologie et informatique médicale (RADIO) author Ashton Nicholas J Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.,Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute, King's College London, London, UK.,NIHR Biomedical Research Centre for Mental Health and Biomedical Research, Unit for Dementia, South London and Maudsley, NHS Foundation, London, UK.,Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway. author Zetterberg Henrik 0000-0003-3930-4354 Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.,Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.,Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.,UK Dementia Research Institute, UCL, London, UK.,Hong Kong Center for Neurodegenerative Diseases, Hong Kong, People's Republic of China. author Blennow Kaj Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden. author Kern Ilse Division of Laboratory Medicine, Diagnostic Department, Geneva University Hospitals, Geneva, Switzerland. 26726 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Frias Miguel 0000-0001-6884-4793 Division of Laboratory Medicine, Diagnostic Department, Geneva University Hospitals, Geneva, Switzerland. 502571 author Garibotto Valentina 0000-0003-2422-698X Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland. 704817 Département de radiologie et informatique médicale (RADIO) author Frisoni Giovanni Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.,Geneva Memory Center, Geneva University Hospitals, Geneva, Switzerland. 810190 dept de réadaptation et gériatrie (MIGRG) 420-427 10.1136/jnnp-2022-330619 37012066 0022-3050 PMC10314086 https://jnnp.bmj.com/content/94/6/420 Background: The key Alzheimer's disease (AD) biomarkers are traditionally measured with techniques/exams that are either expensive (amyloid-positron emission tomography (PET) and tau-PET), invasive (cerebrospinal fluid Aβ42 and p-tau181), or poorly specific (atrophy on MRI and hypometabolism on fluorodeoxyglucose-PET). Recently developed plasma biomarkers could significantly enhance the efficiency of the diagnostic pathway in memory clinics and improve patient care. This study aimed to: (1) confirm the correlations between plasma and traditional AD biomarkers, (2) assess the diagnostic accuracy of plasma biomarkers as compared with traditional biomarkers, and (3) estimate the proportion of traditional exams potentially saved thanks to the use of plasma biomarkers. Methods: Participants were 200 patients with plasma biomarkers and at least one traditional biomarker collected within 12 months. Results: Overall, plasma biomarkers significantly correlated with biomarkers assessed through traditional techniques: up to r=0.50 (p<0.001) among amyloid, r=0.43 (p=0.002) among tau, and r=-0.23 (p=0.001) among neurodegeneration biomarkers. Moreover, plasma biomarkers showed high accuracy in discriminating the biomarker status (normal or abnormal) determined by using traditional biomarkers: up to area under the curve (AUC)=0.87 for amyloid, AUC=0.82 for tau, and AUC=0.63 for neurodegeneration status. The use of plasma as a gateway to traditional biomarkers using cohort-specific thresholds (with 95% sensitivity and 95% specificity) could save up to 49% of amyloid, 38% of tau, and 16% of neurodegeneration biomarkers. Conclusion: The implementation of plasma biomarkers could save a remarkable proportion of more expensive traditional exams, making the diagnostic workup more cost-effective and improving patient care. CSF PET Alzheimer's disease Dementia Memory Humans Alzheimer Disease / diagnostic imaging Tau Proteins / cerebrospinal fluid Amyloid beta-Peptides / cerebrospinal fluid Biomarkers / cerebrospinal fluid Positron-Emission Tomography Peptide Fragments / cerebrospinal fluid Cognitive Dysfunction / diagnosis Dewey 616.8 Dewey 616.0757 Dewey 616 Dewey 618.97 Swiss National Science Foundation The Biological Basis of Cognitive Impairment due to Suspected Non-Alzheimer’s Pathology (SNAP) : Studying the interplay between amyloidosis and tau-related neurodegeneration 169876 CH Projects Swiss National Science Foundation Individual cognitive risk profiling in aging according to Amyloid, Tau and Neurodegeneration imaging biomarkers 185028 CH Projects Swiss National Science Foundation Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): correlation with clinical features and in vivo neuropathology 182772 CH Projects Swiss National Science Foundation CLearing Alzheimer’s disease Molecular Pathology without medications (CLAMP) 196354 CH Projects Swiss National Science Foundation Individual cognitive risk profiling in aging according to Amyloid, Tau and Neurodegeneration imaging biomarkers 185028 CH Projects European Commission Study of tau strains to understand the phenotypic diversity of Alzheimer’s disease: A step toward personalized therapies 839098 DIVE into AD EU H2020 Swedish Research Counci 2018-02532 European Commission Pathways to Alzheimer's disease 681712 PATHAD EU H2020 European Commission Fluid Biomarkers for Neurodegenerative Dementias 101053962 FLUBIODEM EU HE Swedish State Support for Clinical Research ALFGBG-71320 Alzheimer Drug Discovery Foundation (ADDF) 201809-2016862 Alzheimer's Association #AACSF-19-617308 & #ADSF-21-831376-C, #ADSF-21-831381-C and #ADSF-21-831377-C European Commission Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis 860197 MIRIADE EU H2020 Swiss National Science Foundation Strategic roadmap for the translation of tau biomarkers in the clinic: an international task force 188355 CH Science communication Velux foundation 1123 European Commission European Prevention of Alzheimer’s Dementia Consortium 115736 EPAD EU FP7 European Commission Amyloid imaging to Prevent Alzheimer’s Disease – Sofia ref.: 115952 115952 AMYPAD EU H2020 62 Département de radiologie et informatique médicale 227 16 Centre interfacultaire de neurosciences 0D9 65 Département de réadaptation et gériatrie 22B 56 Département de médecine 221 false 926 Imagerie per-opératoire multi-modalité en radiologie interventionnelle 949 1222 Laboratoire de neuroimagerie et de traceurs moléculaires innovants 984 1132 LANVIE - Laboratoire de Neuroimagerie 853 Troubles de mémoire et maladie d'Alzeimer 935 Journal of neurology, neurosurgery and psychiatry 94 6 e4b797b6-59e6-4500-8803-6c72689672c5 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 884468 application/pdf CC BY-NC-4.0 ad1986e25430d227a79768102e0d19763ac5b32c8cd0ef75cd681a2bacaf8a1d 8943a991-ee72-4c8b-9daa-1d063e30b88f Supplemental data Public jnnp-2022-330619supp001_data_supple.pdf 11127648 application/pdf Supplementary Tables & Figures f165c8c242cf63815e642e1c1afa7d396df021e6404262f5f5881c46940020f8 openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Centres et instituts / Centre interfacultaire de neurosciences Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie Faculté de médecine / Section de médecine clinique / Département de médecine

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Plasma biomarkers for Alzheimer's disease: a field-test in a memory clinic	Journal of neurology, neurosurgery and psychiatry			2023	274	288

Archive ouverte UNIGE

Bancila, Bianca

account_balance Affiliation entities

Affiliation entities