Development and validation of LC-MS/MS method to phenotyping NAT2 in DBS using caffeine as probe drug and genotype/phenotype correlation

Diplôme Master Development and validation of LC-MS/MS method to phenotyping NAT2 in DBS using caffeine as probe drug and genotype/phenotype correlation eng 2020 author Skhiri M'Hamed 839119 director Desmeules Jules Alexandre 73542 The variability of a drug's response between patients is an expected feature of most drug treatments, it can lead to therapeutic failures or unwanted adverse drug reactions. This therapeutic phenomenon is increased by pharmacokinetic variability implying that, for the same dose, the effective drug concentration in body fluids is highly variable. In addition to pharmacokinetics, the interindividual pharmacodynamic variability impacts the response of receptors in equal concentration of drug. This work is focused on polymorphism in drug metabolizing enzymes, especially N-acetyltransferase 2 (NAT2). Anthropology DBS Development method Genotype Metabolic ratio NAT2 Phenotype Polymorphism DME Dewey 615 Master en pharmacie 31 Section des sciences pharmaceutiques 17 false 99b79d7a-fbb8-4866-94b0-530c538c515a Master thesis Restricted 200731110647_skhiri5__TPR.pdf 1960451 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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Development and validation of LC-MS/MS method to phenotyping NAT2 in DBS using caffeine as probe drug and genotype/phenotype correlation				2020	69	4

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Skhiri, M'Hamed